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Opportunities, Challenges, and Lessons of International Research in Practice-Based Research Networks: The Case of an International Study of Acute Otitis Media

Larry A. Green, MD¹, George E. Fryer, Jr, PhD¹, Paul Froom, MD², Larry Culpepper, MD³ and Jack Froom, MD^4,

¹ The Robert Graham Center, Washington, DC
² Hematology Laboratories, Clalit Health Services, Nesher, Israel
³ Department of Family Medicine, Boston University, Boston, Mass
⁴ Department of Family Medicine, State University of New York, Stoney Brook, Stoney Brook, NY

CORRESPONDING AUTHOR: Larry A. Green, MD The Robert Graham Center, Suite 201 1350 Connecticut Avenue, NW Washington, DC 22036 Lgreen{at}aafp.org

The requirements of research become more complex and demanding in international collaborations. The opportunity to study naturally occurring variation in treatment prompted networking primary care research networks in the United Kingdom, the Netherlands, and North America to study acute otitis media. Additional challenges faced and addressed in this study included (1) differing national requirements for protecting human subjects; (2) variation in data collection processes in primary care practices; (3) data transmission among participants; (4) duties and tariffs on necessary instruments; (5) fluctuation in currency exchange rates; (6) incapacitation of coinvestigators; (7) complex administration of funds; (8) financing the additional, legitimate costs of collaboration; (9) sustaining strong personal relationships among coinvestigators; and (10) accepting longer time frames than would otherwise be expected. Overall, international practice-based research can be productive, affect millions of people, and be extremely rewarding to investigators. It is not, however, for the faint-hearted.

Key Words: International research • international cooperation • practice-based research/methods • research design • otitis media

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