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Annals of Family Medicine 7:212-222 (2009)
© 2009 Annals of Family Medicine, Inc.
doi: 10.1370/afm.942
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Cumulative Incidence of False-Positive Results in Repeated, Multimodal Cancer Screening

Jennifer Miller Croswell, MD*, Barnett S. Kramer, MD, MPH*, Aimee R. Kreimer, PhD, Phil C. Prorok, PhD, Jian-Lun Xu, PhD, Stuart G. Baker, ScD, Richard Fagerstrom, PhD, Thomas L. Riley, Jonathan D. Clapp, Christine D. Berg, MD, John K. Gohagan, PhD, Gerald L. Andriole, MD, David Chia, PhD, Timothy R. Church, PhD, E. David Crawford, MD, Mona N. Fouad, MD, MPH, Edward P. Gelmann, MD, Lois Lamerato, PhD, MS, Douglas J. Reding, MD, MPH and Robert E. Schoen, MD, MPH

National Institutes of Health, Office of the Director, Office of Disease Prevention, Bethesda, Maryland (Croswell, Kramer); National Institutes of Health, National Cancer Institute, Division of Cancer Prevention, Bethesda, Maryland (Kreimer, Xu, Baker, Fagerstrom, Berg, Gohagan); IMS, Incorporated, Washington, DC (Riley, Clapp); Washington University School of Medicine, St. Louis, Missouri (Andriole); UCLA School of Medicine, Los Angeles, California (Chia); University of Minnesota School of Public Health, Minneapolis, Minnesota (Church); University of Colorado Health Sciences Center, Aurora, Colorado (Crawford); University of Alabama at Birmingham, Birmingham, Alabama (Fouad); Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York (Gelmann); Henry Ford Health System, Detroit, Michigan (Lamerato); Marshfield Clinic Research Foundation, Marshfield, Wisconsin (Reding); University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (Schoen).


Figure 1
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  		Figure 1. Study population selection.

 

Figure 2
Figure 2
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  		Figure 2. Cumulative probability of a false-positive result for a multimodal cancer screening regimen.

 

Figure 3
Figure 3
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  		Figure 3. Cumulative probability of receiving an invasive diagnostic procedurea as a direct result of a false-positive test in a multimodal cancer screening regimen.

 




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