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Original Research:
David Rabago, Bruce Barrett, Lucille Marchand, Rob Maberry, and Marlon Mundt
Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study
Ann Fam Med 2006; 4: 295-301 [Abstract] [Full text] [PDF]
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Electronic letters published:

[Read Comment] Pulsating Irrigation 3 X more effective than non pulsating irrigation
Glen Rocklin   (15 December 2007)
[Read Comment] Thanks for the comments
David P Rabago   (19 August 2006)
[Read Comment] Re: Commentary on: "Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study"
Judith A Nudelman   (13 August 2006)
[Read Comment] Commentary on: "Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study"
Berrylin J Ferguson   (10 August 2006)
[Read Comment] Pulsatile vs. Non-pulsatile nasal irrigation
Judith A Nudelman   (10 August 2006)
[Read Comment] Nasal Irrigation
Terence M Davidson   (3 August 2006)

Pulsating Irrigation 3 X more effective than non pulsating irrigation 15 December 2007
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Glen Rocklin,
Los Angeles, USA
Mfg

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Re: Pulsating Irrigation 3 X more effective than non pulsating irrigation

As a former Sr. executive at Teledyne Water Pik for nearly 20 years I am continually surprised at the general lack of knowledge with regards to the significant advantages of pulsatile lavage vs non pulsating irrigation for breaking down biofilm and removing bacteria within the otolaryngolical profession.

A standard treatment for the past 30 years throughout trauma centers across the United States for wound irrigation and bacteria removal it is well documented that pulse irrigation is up to 3X more effective at removing bacteria over steady stream irrigation.

Where Neti pots require gravity and an ill placed position of the head (tilted) to irrigate which could exacerbate ear discomfort the mechanical pulse irrigator provides greater control, head placement, and less pressure (5 psi).

The advantage of intermittant pulse lavage is that it is uses less presure but more leverage to remove bacteria and break down biofilm from uneven surface areas of tissues. In addition the 1200 PPM intermittant pulse lavage has been reported to help stimulate nasal clia movement over steady stream irrigation.

References

Early Wound Irrigation Improves the Ability to Remove Bacteria Owens and Wenke J Bone Am.2007; 89: 1723-1726

Using Pulsatile Pressure Saline/Antibiotic Irrigation, Betts N. et al. Compendium Contin Educa Dent, 17(9): 871 1996. The efficacy of pulsatile saline irrigation in removing bacteria has been demonstrated.

20. Stewart JL, Carlson HC, Briggs RL, Green VA. The bacteria-removal efficiency of mechanical pulsatile lavage Pathol. 1971;31(6):842-848.

Lavage of contaminated surfaces: an in vitro evaluation of the effectiveness of different systems. Journal of Surgical Research, Volume 112, Issue 1, Pages 26-30 C. Bahrs

MARVIN F. GROWER and SURINDAR N. BHASKAR Dental Corps, United States Army Institute of Dental Research, Walter Reed Army Medical Center, Washington, DC 20012, USAEffect of Pulsating Water Jet Lavage on Radioactive Contaminated Wounds. The single stream water jet device was about 2.5 times more effective than the conventional bulb syringe in removing the radioactive material.

7. Anglen J, Apostoles S, Christensen G, Gainor B. The efficacy of various irrigation solutions in removing slime-producing staphylococcus. J Orthopaed Trauma 1994;8(5):390-6.

Pulsed Lavage in Cleansing Kathleen A Luedtke-Hoffmann and D Sue Schafer KA Luedtke-Hoffmann, PT, MBA, is a doctoral candidate in physical therapy in the School of Physical Therapy, Texas Woman's University, 8194 Walnut Hill Ln, Dallas, TX 75231 (USA) (kluedtke@twu.edu). This article was written in partial fulfillment of her graduate degree. Address all correspondence to Ms Luedtke-Hoffmann DS Schafer, PT, PhD, is the Associate Dean for the School of Physical Therapy, Texas Woman's University, Dallas

Competing interests:   None declared

Thanks for the comments 19 August 2006
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David P Rabago,
Madison, USA
MD

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Re: Thanks for the comments

From the first author.

My thanks for the discussion here. It's a good forum for communication on publications, and allows readers and authors to go one step further.

The comments thus far are very intersting. Thanks for the praises, this was a rewarding project, and did indeed result in generally happy subjects.

Re hypertonic vs normal saline, I agree that the debate will go on. As well as with additions to the saline. A recent paper documented Dead sea salt irrigations as being more effective than NaCl for chronic sinus symptoms. RCTs to delineate these issues are fine, but they are time- consuming and expensive. In our center we go through some options with pts about salt, sodium bicarb and temperature and let them experiment within safe parameters. Different pt seem to prefer different solutions, yet have good results.

Re neti pots vs pulsatile devices, I think the main thing is getting the saline into the nasal cavity, though I am not aware of a head to head trial. Different patients would likely prefer different vessels, again the best at this time might be to offer the choice. I am unaware of different rates of harm in either case.

Re the use of nasal irrigation for rhinitis, that is an an excellent next RCT. One group in Italy has documented excellent results with nasal saline for peds seasonal allergic rhinositis. Our group plans a second look at our data to determine if subjects with allergic rhinitis had equally effective results in all three parts of the study.

Thanks again for the comments, I will continue to respond to comments and questions. David

Competing interests:   None declared

Re: Commentary on: "Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study" 13 August 2006
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Judith A Nudelman,
Barrington,RI USA
Family Physician, Brown Medical School

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Re: Re: Commentary on: "Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study"

What an excellent comment/commentary. It serves as an additional reference to the article.

Competing interests:   None declared

Commentary on: "Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study" 10 August 2006
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Berrylin J Ferguson,
Pittsburgh, USA
M.D., University of Pittsburgh School of Medicine

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Re: Commentary on: "Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study"

The authors report on the quality of life improvements and reflections of over two dozen individuals utilizing hypertonic saline nasal irrigation on an as needed basis. The findings provide validation of the anecdotal experience of many rhinologists. Unique to this study was an apparent added benefit of group training and discussions, which gave these sufferers an additional benefit conferred from “group support”, a benefit acknowledged in many disease states from cancer support groups to chronic debilitating diseases. I had not previously considered that this kind of group support might be helpful for chronic rhinosinusitis, but from the interviews it appears that it is indeed appreciated by the participants.

I can think of no way to perform a blinded controlled study of nasal irrigations, but that doesn’t mean they are not effective. In fact, the efficacy of the irrigation frequently overshadows the efficacy of any number of added ingredients including antifungals, antibacterials, and topical steroids.1 The irrigation serves to remove nasal debris in noses that are not self-cleaning, which is particularly a problem in patients with nasal polyps or who have undergone extensive sinus/nasal surgery.

Nasal irrigation can also be helpful as a rinse to remove mucus before the application of a topical steroid or antibiotic. I commonly recommend a commercial nasal lavage kit, of which there are a half dozen or so available to assist with compliance. There are many commercially available nasal irrigators.2 I also provide our patients with a “recipe” so that they can make their own saline irrigation. Patients should be warned to use filtered or boiled water, and to make sure the device used for irrigation is cleaned frequently to prevent iatrogenic inoculation with water loving microbes such as Pseudomonas and Serratia.

The debate of hypertonic versus normal saline irrigation is sure to continue.3 I usually provide the patient with the recipe for hypertonic saline and suggest that they reduce the amount of salt they add, if they find that the hypertonic mixture is irritating. Interestingly, hypertonic inhaled saline has been shown to be beneficial in cystic fibrosis.4 Seven percent of patients with chronic rhinosinusitis carry a mutation for cystic fibrosis compared to 2% of normal controls. Thus there may be a variance in response to hypertonic versus isotonic saline irrigations, depending on the cause of the patient’s rhinosinusitis.5

Finally, the authors capture in a qualitative manner the relief that patients feel with this technique. I still recall the words of a patient on her return visit, “I can't believe I've been suffering for 30 years with the sinus condition when relief was as easy and inexpensive as this salt water wash." A trial of hypertonic or isotonic saline nasal rinse is inexpensive, does not promote bacterial resistance, and safe. Saline irrigations should be a therapeutic alternative offered to any patients suffering from chronic rhinosinusitis.

References

1. Ferguson BJ. Antifungal Nasal Washes for Chronic Rhinosinusitis: What's Therapeutic -- The Watch or the Antifungal? J Allergy Clin Immunology 2003;111(11)37-8.

2. Tomooka LT, Murphy C, Davidson TM. Clinical Study Literature Review of Nasal Irrigation. Laryngoscope 2000;110(11)89-93.

3. Garavello W, Romagnoli M, Gaini RM. Hypertonic or Ice Tonic Saline for Allergic Rhinitis in Children. Pediatric Allergy and Immunology 2005;16:91.

4. Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks GB, Belousova EG, Xuan W, Bye PT. National Hypertonic Saline in Cystic Fibrosis (NHSCF) Study Group. A Controlled Trial of Long-term Inhaled Hypertonic Saline in Patients with Cystic Fibrosis. N Engl J Med 2006;354:229-240.

5. Wang X, Moylan B, Leopold DA, Kim J, Rubenstein RC, Togias A, Proud D, Zeitlin PL, Cutting GR. Mutation in the Gene Responsible for Cystic Fibrosis and Predisposition to Chronic Rhinosinusitis in the General Population. JAMA 2000;284:1814-1819.

Competing interests:   None declared

Pulsatile vs. Non-pulsatile nasal irrigation 10 August 2006
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Judith A Nudelman,
Barrington,RI USA
Family Physician, Brown Medical School

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Re: Pulsatile vs. Non-pulsatile nasal irrigation

I am a family physician who has both treated many patients with sinusitis, and has had sinus disease for decades. I've used both pulsatile irrigation (Water Pik with Grossan head) and more recently, the neti pot for the last seven years. As your article addressed patients' sense of control over the disease primarily, I feel that the neti pot irrigation has several benefits. It is considerably less expensive and easily cleaned. If one is not careful, the tubing in the Grossan irrigator or Water pik can become colonized, as all wet tubing as the ability to form biofilms. My ENT has preferred the neti pot for at least a decade, citing low pressure, high flow and head position that encourages ethmoid irrigation. Rather than a matter of preference: pulsatile vs. non-pulsatile irrigation, I would like to see RTC's exploring the two methods. I do feel that the significantly lower cost and ease of cleaning favor the simple neti pot. However, if pulsatile irrigation would significantly decrease sinus disease over non-pulsatile irrigation, the initial cost and need to rigorously cleanse the device would become a moot point. I welcome additional studies.

Competing interests:   None declared

Nasal Irrigation 3 August 2006
 Next Comment Top
Terence M Davidson,
San Diego, CA, USA
Director UCSD Nasal Dysfunction Clinic, UCSD School of Medicine

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Re: Nasal Irrigation

What a great paper. My clinical experience with over 3000 patients supports the findings. This works equally well for atrophic rhinitis, aging rhinitis and to a lesser degree for allergic rhinitis Pulsatile irrigation is superior to non pulsatile. Just as pulsatile irrigation is supperior for cleaning your teeth or cleaning a wound, the pulsatile irrigation does a superior job of dislodging thick mucus and debris. My preferred irrigation systems are the Grossan and the WaterPik with Ethicare nasal adaptor. Further information on their use is found in my website, drdavidson.ucsd.edu, fileURL:http://www.drdavidson.ucsd.edu/Portals/0/nasal.htm

Competing interests:   None declared


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