Objective: This report describes the participants and compares the acute and longer-term
treatment outcomes associated with each of four successive steps in the Sequenced Treatment …

OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression,
but the rates, timing, and baseline predictors of remission in “real world” patients are …

Background Although clinicians frequently add a second medication to an initial, ineffective
antidepressant drug, no randomized controlled trial has compared the efficacy of this …

Background After unsuccessful treatment for depression with a selective serotonin-reuptake
inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective …

Objective: About half of outpatients with major depressive disorder also have clinically
meaningful levels of anxiety. The authors conducted a secondary data analysis to compare …

The Sequenced Treatment Alternatives to Relieve Depression trial enrolled outpatients with
nonpsychotic major depressive disorder treated prospectively in a series of randomized …

Design The rationale and design of the study have been fully described elsewhere (3, 4, 9).
STAR* D is the largest prospective clinical trial of major depressive disorder ever conducted. …

Objective: More than 40% of patients with major depressive disorder do not achieve
remission even after two optimally delivered trials of antidepressant medications. This study …

Objective: The authors compared the effectiveness of cognitive therapy and pharmacotherapy
as second-step strategies for outpatients with major depressive disorder who had …

Objective: Two antidepressant medication combinations were compared with selective
serotonin reuptake inhibitor monotherapy to determine whether either combination produced a …