Background Uncontrolled pilot studies have suggested the efficacy of focused ultrasound
thalamotomy with magnetic resonance imaging (MRI) guidance for the treatment of essential …

Context Treating hypertension decreases mortality and disability from cardiovascular disease,
but most hypertension remains inadequately controlled. Objective To determine if a new …

As the patient-centered medical home model emerges as a key vehicle to improve the
quality of health care and to control costs, the experience of Seattle-based Group Health …

Objective To determine the estimates of minimal, moderate, and large clinically important
differences (CIDs) for the Unified Parkinson's Disease Rating Scale (UPDRS). Design Cross-…

OBJECTIVE: To determine the healthcare utilization and medical care costs of women with
a history of intimate partner violence (IPV) compared to women without a history of IPV. …

The objectives of this study are to assess the level of disease severity associated with
disability in Parkinson disease (PD) and the sequence of loss of independence in basic and …

Objectives. Develop and estimate the RxRisk model, a risk assessment instrument that uses
automated ambulatory pharmacy data to identify chronic conditions and predict future health …

Parkin, the most commonly mutated gene in familial Parkinson's disease, encodes an E3
ubiquitin ligase. A number of candidate substrates have been identified for parkin ubiquitin …

Background. Assessment of disease burden is the key to many aspects of health care
management. Patient diagnoses are commonly used for case-mix assessment. However, issues …

Background Unilateral focused ultrasound ablation of the internal segment of globus pallidus
has reduced motor symptoms of Parkinson’s disease in open-label studies. Methods We …