Background Despite the importance of functional status to older persons and their families,
little is known about the course of disability at the end of life. Methods We evaluated data on …

Background: Little is known about the natural course of frailty. We performed a prospective
study to determine the transition rates between frailty states and to evaluate the effect of the …

Background Serum testosterone concentrations decrease as men age, but benefits of raising
testosterone levels in older men have not been established. Methods We assigned 790 …

Background. Little is known about the processes underlying the development of functional
dependence. We set out to determine whether impairments in physical performance and …

ContextPreventing the development of disability in activities of daily living is an important
goal in older adults, yet relatively little is known about the disabling process.ObjectivesTo …

OBJECTIVES: To identify the characteristics associated with restricting activity because of
fear of falling (activity restriction) and to determine which characteristics distinguish older …

Context Disability among older persons is a complex and highly dynamic process, with high
rates of recovery and frequent transitions between states of disability. The role of intervening …

Objective. —To evaluate how well quality of life is being measured in the medical literature
and to offer a new approach to the measurement. Data Sources. —Original English-language …

Background Frailty can be measured in relation to the accumulation of deficits using a frailty
index. A frailty index can be developed from most ageing databases. Our objective is to …

Importance In older adults reduced mobility is common and is an independent risk factor for
morbidity, hospitalization, disability, and mortality. Limited evidence suggests that physical …