PT  - JOURNAL ARTICLE
AU  - Larry A. Green
AU  - George E. Fryer, Jr
AU  - Paul Froom
AU  - Larry Culpepper
AU  - Jack Froom
TI  - Opportunities, Challenges, and Lessons of International Research in Practice-Based Research Networks: The Case of an International Study of Acute Otitis Media
AID  - 10.1370/afm.224
DP  - 2004 Sep 01
TA  - The Annals of Family Medicine
PG  - 429--433
VI  - 2
IP  - 5
4099  - http://www.annfammed.org/content/2/5/429.short
4100  - http://www.annfammed.org/content/2/5/429.full
SO  - Ann Fam Med2004 Sep 01; 2
AB  - The requirements of research become more complex and demanding in international collaborations. The opportunity to study naturally occurring variation in treatment prompted networking primary care research networks in the United Kingdom, the Netherlands, and North America to study acute otitis media. Additional challenges faced and addressed in this study included (1) differing national requirements for protecting human subjects; (2) variation in data collection processes in primary care practices; (3) data transmission among participants; (4) duties and tariffs on necessary instruments; (5) fluctuation in currency exchange rates; (6) incapacitation of coinvestigators; (7) complex administration of funds; (8) financing the additional, legitimate costs of collaboration; (9) sustaining strong personal relationships among coinvestigators; and (10) accepting longer time frames than would otherwise be expected. Overall, international practice-based research can be productive, affect millions of people, and be extremely rewarding to investigators. It is not, however, for the faint-hearted.