RT Journal Article SR Electronic T1 Opportunities, Challenges, and Lessons of International Research in Practice-Based Research Networks: The Case of an International Study of Acute Otitis Media JF The Annals of Family Medicine JO Ann Fam Med FD American Academy of Family Physicians SP 429 OP 433 DO 10.1370/afm.224 VO 2 IS 5 A1 Green, Larry A. A1 Fryer, George E. A1 Froom, Paul A1 Culpepper, Larry A1 Froom, Jack YR 2004 UL http://www.annfammed.org/content/2/5/429.abstract AB The requirements of research become more complex and demanding in international collaborations. The opportunity to study naturally occurring variation in treatment prompted networking primary care research networks in the United Kingdom, the Netherlands, and North America to study acute otitis media. Additional challenges faced and addressed in this study included (1) differing national requirements for protecting human subjects; (2) variation in data collection processes in primary care practices; (3) data transmission among participants; (4) duties and tariffs on necessary instruments; (5) fluctuation in currency exchange rates; (6) incapacitation of coinvestigators; (7) complex administration of funds; (8) financing the additional, legitimate costs of collaboration; (9) sustaining strong personal relationships among coinvestigators; and (10) accepting longer time frames than would otherwise be expected. Overall, international practice-based research can be productive, affect millions of people, and be extremely rewarding to investigators. It is not, however, for the faint-hearted.