PT  - JOURNAL ARTICLE
AU  - Velásquez, Esther E.
AU  - Kamdar, Neil S.
AU  - Rehkopf, David H.
AU  - Saydah, Sharon
AU  - Bull-Otterson, Lara
AU  - Hao, Shiying
AU  - Vala, Ayin
AU  - Chu, Isabella
AU  - Bazemore, Andrew W.
AU  - Phillips, Robert L.
AU  - Boehmer, Tegan
TI  - Post-COVID Conditions in US Primary Care: A PRIME Registry Comparison of Patients With COVID-19, Influenza-Like Illness, and Wellness Visits
AID  - 10.1370/afm.3131
DP  - 2024 Jul 01
TA  - The Annals of Family Medicine
PG  - 279--287
VI  - 22
IP  - 4
4099  - http://www.annfammed.org/content/22/4/279.short
4100  - http://www.annfammed.org/content/22/4/279.full
SO  - Ann Fam Med2024 Jul 01; 22
AB  - PURPOSE COVID-19 is a condition that can lead to other chronic conditions. These conditions are frequently diagnosed in the primary care setting. We used a novel primary care registry to quantify the burden of post-COVID conditions among adult patients with a COVID-19 diagnosis across the United States.METHODS We used the American Family Cohort, a national primary care registry, to identify study patients. After propensity score matching, we assessed the prevalence of 17 condition categories individually and cumulatively, comparing patients having COVID-19 in 2020-2021 with (1) historical control patients having influenza-like illness in 2018 and (2) contemporaneous control patients seen for wellness or preventive visits in 2020-2021.RESULTS We identified 28,215 patients with a COVID-19 diagnosis and 235,953 historical control patients with influenza-like illness. The COVID-19 group had higher prevalences of breathing difficulties (4.2% vs 1.9%), type 2 diabetes (12.0% vs 10.2%), fatigue (3.9% vs 2.2%), and sleep disturbances (3.5% vs 2.4%). There were no differences, however, in the postdiagnosis monthly trend in cumulative morbidity between the COVID-19 patients (trend = 0.026; 95% CI, 0.025-0.027) and the patients with influenza-like illness (trend = 0.026; 95% CI, 0.023-0.027). Relative to contemporaneous wellness control patients, COVID-19 patients had higher prevalences of breathing difficulties and type 2 diabetes.CONCLUSIONS Our findings show a moderate burden of post-COVID conditions in primary care, including breathing difficulties, fatigue, and sleep disturbances. Based on clinical registry data, the prevalence of post-COVID conditions in primary care practices is lower than that reported in subspecialty and hospital settings.