RT Journal Article SR Electronic T1 Descriptive epidemiology of pathogens associated with acute respiratory infection in a study of K-12 school children JF The Annals of Family Medicine JO Ann Fam Med FD American Academy of Family Physicians SP 6229 DO 10.1370/afm.22.s1.6229 VO 22 IS Supplement 1 A1 Temte, Jonathan A1 Walters, Sarah A1 Sethi, Ajay A1 Hamer, Caroline A1 He, Cecilia A1 Barlow, Shari A1 Uzicanin, Amra A1 Goss, Maureen A1 Temte, Emily YR 2024 UL http://www.annfammed.org/content/22/Supplement_1/6229.abstract AB Context: School-based outbreaks often precede increased incidence of acute respiratory infections in the greater community.Objective: We evaluated acute respiratory infections (ARI) among school-aged children in a southcentral Wisconsin school district over 8.5 consecutive years to elucidate commonly detected pathogens, their unique characteristics, and epidemiological patterns.Study Design and Analysis: The ORegon CHild Absenteeism due to Respiratory Disease Study (ORCHARDS) is a longitudinal, laboratory-supported, school-based, ARI surveillance study designed to monitor respiratory virus activity in kindergarten through 12th grade schools.Setting: Oregon School District, Dane County, Wisconsin, USA, between January 2015 and June 2023, and before and after emergence of SARS-CoV-2.Population Studied: Children aged 4—12 years meeting criteria for ARI.Intervention/Instrument: Eligible participants with ARIs provided demographic, epidemiologic, and symptom data, along with a nasal swab or oropharyngeal specimen. Multipathogen testing using reverse-transcription polymerase chain reaction (RT-PCR) was performed on all specimens for 18 respiratory viruses (including SARS-CoV-2 starting September 2019) and two atypical bacterial pathogens.Outcome Measures: Pathogen identification.Results: Between January 5, 2025, and June 9, 2023, 3,498 children participated in ORCHARDS. Pathogens were detected in 2,455 of 3,498 (70%) specimens. Rhinovirus/enteroviruses (36%), influenza viruses A/B (35%), and seasonal coronaviruses (11%) were most commonly identified in positive specimens. Rhinovirus/enteroviruses and parainfluenza viruses occurred early in the academic year, followed by seasonal coronaviruses, RSV, influenza A, influenza B, and human metapneumovirus. Students who reported their possible source of infection most often cited a family member (49.6%) or classmate (34.6%). Seasonal coronaviruses, SARS-CoV-2, influenza B virus, and rhino/enteroviruses were more common in older students (>10 years of age) and RSV, parainfluenza virus, influenza A virus, human metapneumovirus, and adenoviruses were more common in younger children (<10 years of age).Conclusion: Since its emergence in 2020, SARS-CoV-2 was detected year-round and with a higher median age than other pathogens. Better understanding of the etiology, presentations, and patterns of pediatric acute respiratory infections can help inform medical and public health system responses to future outbreaks.