RT Journal Article
SR Electronic
T1 Sleep Apnea and Risk of Panic Disorder
JF The Annals of Family Medicine
JO Ann Fam Med
FD American Academy of Family Physicians
SP 325
OP 330
DO 10.1370/afm.1815
VO 13
IS 4
A1 Vincent Yi-Fong Su
A1 Yung-Tai Chen
A1 Wei-Chen Lin
A1 Li-An Wu
A1 Shi-Chuan Chang
A1 Diahn-Warng Perng
A1 Wei-Juin Su
A1 Yuh-Min Chen
A1 Tzeng-Ji Chen
A1 Yu-Chin Lee
A1 Kun-Ta Chou
YR 2015
UL http://www.annfammed.org/content/13/4/325.abstract
AB PURPOSE Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of sleep apnea. The relationship between sleep apnea and subsequent panic disorder, however, remains unclear.METHODS Using a nationwide database, the Taiwan National Health Insurance Research Database, patients with sleep apnea and age-, sex-, income-, and urbanization-matched control patients who did not have sleep apnea were enrolled between 2000 and 2010. Patients with a prior diagnosis of panic disorder before enrollment were excluded. The 2 cohorts were observed until December 31, 2010. The primary endpoint was occurrence of newly diagnosed panic disorder.RESULTS A total of 8,704 sleep apnea patients and 34,792 control patients were enrolled. Of the 43,496 patients, 263 (0.60%) suffered from panic disorder during a mean follow-up period of 3.92 years, including 117 (1.34%) from the sleep apnea cohort and 146 (0.42%) from the control group. The Kaplan-Meier analysis revealed a predisposition of patients with sleep apnea to develop panic disorder (log-rank test, P <.001). After multivariate adjustment, the hazard ratio for subsequent panic disorder among the sleep apnea patients was 2.17 (95% confidence interval, 1.68–2.81; P <.001).CONCLUSIONS Sleep apnea appears to confer a higher risk for future development of panic disorder.