RT Journal Article
SR Electronic
T1 Heplisav-B vs Standard Hepatitis B Vaccine Booster for Health Care Workers
JF The Annals of Family Medicine
JO Ann Fam Med
FD American Academy of Family Physicians
SP 162
OP 164
DO 10.1370/afm.240184
VO 23
IS 2
A1 Williams, Alan L.
A1 Newman, Raquelle S.
YR 2025
UL http://www.annfammed.org/content/23/2/162.abstract
AB Confidence in hepatitis B seroprotection for US health care workers includes a complete immunization series followed by a hepatitis B surface antigen antibody (anti-HBs) titer ≥10 mIU/mL. We compared standard hepatitis B vaccines to Heplisav-B (Dynavax Technologies Corp) as a single booster for young, healthy, previously vaccinated individuals. Participants (N = 242) had documentation of a single vaccination series and an anti-HBs titer <10 mIU/mL. In this cohort, 1 booster achieved seropositivity for 92.7% (95% CI, 84.8%-97.2%) of the standard hepatitis B vaccine group and 99.4% (95% CI, 96.6%-100.0%) of the Heplisav-B group. Both boosters are likely to produce seropositivity in this population.