@article {Dupouy355, author = {Julie Dupouy and Aurore Palmaro and M{\'e}lina Fats{\'e}as and Marc Auriacombe and Jo{\"e}lle Micallef and St{\'e}phane Oustric and Maryse Lapeyre-Mestre}, title = {Mortality Associated With Time in and Out of Buprenorphine Treatment in French Office-Based General Practice: A 7-Year Cohort Study}, volume = {15}, number = {4}, pages = {355--358}, year = {2017}, doi = {10.1370/afm.2098}, publisher = {The Annals of Family Medicine}, abstract = {In France, most cases of opioid use disorder are treated with buprenorphine by general practitioners in private practice. Using reimbursement data of a representative sample of the French population, Echantillon G{\'e}n{\'e}raliste des B{\'e}n{\'e}ficiaires, we investigated mortality during periods when patients were in and out of treatment in a cohort of 713 new users of buprenorphine having a mean (SD) follow-up of 4.5 (1.5) years. The mortality rate was 0.63 per 100 person-years (95\% CI, 0.40{\textendash}0.85) overall. In a multivariate Cox regression model, compared with being in treatment, being out of treatment was associated with a markedly increased risk of death (hazard ratio = 29.04; 95\% CI, 10.04{\textendash}83.99). Buprenorphine appears to be a strong protective factor against mortality.}, issn = {1544-1709}, URL = {https://www.annfammed.org/content/15/4/355}, eprint = {https://www.annfammed.org/content/15/4/355.full.pdf}, journal = {The Annals of Family Medicine} }