RT Journal Article SR Electronic T1 The Relationship Between Oseltamivir and Suicide in Pediatric Patients JF The Annals of Family Medicine JO Ann Fam Med FD American Academy of Family Physicians SP 145 OP 148 DO 10.1370/afm.2183 VO 16 IS 2 A1 Harrington, Rachel A1 Adimadhyam, Sruthi A1 Lee, Todd A. A1 Schumock, Glen T. A1 Antoon, James W. YR 2018 UL http://www.annfammed.org/content/16/2/145.abstract AB PURPOSE Studies examining the association between use of oseltamivir and neuropsychiatric events (including suicide) among children have had mixed findings and have been limited by small sample size, reliance on older data, and potential confounding. We undertook an analysis that addresses these limitations.METHODS Using a national administrative claims database and a case-crossover design that minimized confounding, we analyzed data from 5 contemporary influenza seasons (2009–2013) for individuals aged 1 to 18 years and ascertained oseltamivir exposure from pharmacy dispensing.RESULTS We identified 21,407 suicide-related events during this study period, 251 of which were in oseltamivir-exposed children. In case-crossover analysis, we did not find any significant association with suicide either for oseltamivir exposure (odds ratio = 0.64; 95% CI, 0.39–1.00; P = .05) or for influenza diagnosis alone (odds ratio = 0.63; 95% CI, 0.34–1.08; P = .10).CONCLUSION Our findings suggest that oseltamivir does not increase risk of suicide in the pediatric population.