Table 2.

Characteristics of the 8 Trials Included in Quantitative Meta-Analyses

Trial, Year	Inclusion Criteria	Participants,No.	Lung Cancer Mortality in Control Group, %	Age at Study Entry	Sex, % Male	Median Follow-up, Y	Pack-Years of Smoking at Entry	Current Smokers, %	Country	Screening Years
National Lung Screening Trial Research Team et al,⁵ 2011	Aged 55-74 years, ≥30 pack-years, current smoker or quit within last 15 years	53,454	1.7	NR	59.0	6.5	Median: 48	48	United States	2002-2007
Infante et al,⁷ 2015	Aged 60-74 years, male, smoker of ≥20 pack-years or quit within 10 years	2,450	4.6	Mean: 64.6 years	100.0	8.35	Median: 45; mean: 47	57	Italy	2001-2012
Wille et al,⁸ 2016	Aged 50-70 years, smoker of ≥20 pack-years or exsmoker who had quit after aged 50 years, and within 10 years	4,104	1.9	Mean: 57.9 years	55.2	9.8	Mean: 36	76	Denmark	2004-2008
Paci et al,¹⁹ 2017	Aged 55-69 years, smoker or exsmoker (≥20 pack-years in the last 10 years) who had quit no more than 10 years ago	3,206	3.8	Mean: 60.8 years	64.7	8.5	Median: control, 38; screening, 40	66	Italy	2004-2014
Doroudi et al,²⁰ 2018	Aged 55-74 years, smoker of ≥30 pack-years or quit within last 10 years	3,318	1.6	NR	58.6	5.2	Median: 54	58	United States	2000-2001
Pastorino et al,²¹ 2019	Aged 49-75 years, current smoker ≥20 pack-years or quit within last 10 years, no cancer in last 5 years	4,099	2.3	Median: control, 57 years; screening, 58 years	66.3	6.2	Median: control, 38; screening, 39	Control: 90 screening: 69	Italy	2005-2018
Becker et al,¹⁸ 2020	Aged 50-69 years, ≥25 years of smoking 15 cigarettes per day, or ≥30 years of smoking 10 cigarettes per day, or exsmoker who quit no more than 10 years ago	4,052	2.0	NR	64.7	8.9	NR	62	Germany	2011-2018
de Koning et al,¹¹ 2020	Aged 50-74 years, male, current or former smoker (who had quit within 10 years) who smoked >15 cigarettes per day for >25 years or who smoked >10 cigarettes per day for >30 years	15,789	3.1	Median: 58 years	83.6	10.0	Median: 38	55	Netherlands and Belgium	2003-2015

NR = not reported.