Cognitive Scoring Tools and Their MCIDs
| Scoring Tool | Range, Points | MCID, Points | Interpretation |
|---|---|---|---|
| Cognitive assessments | |||
| ADAS-Cog-11 | 0 to 7024 | 324 | Lower is better |
| ADAS-Cog-12 | 0 to 8025 | 3.5a | Lower is better |
| ADAS-Cog-13 | 0 to 8526 | 3.75a | Lower is better |
| ADAS-Cog-14 | 0 to 9027 | 4a | Lower is better |
| ADCOMS-overall | 0 to 1.9728 | 0.14b | Lower is better |
| Neuropsychological test battery | Z scale29 | 0.5 SD | Higher is better |
| MMSE | 0 to 3030 | 1 to 330 | Higher is better |
| Functional assessments | |||
| ADCS-ADL | 0 to 78 | 5.5b | Higher is better |
| ADCS-ADL-MCI | 0 to 5317 | 3.7b | Higher is better |
| DAD | 0 to 100c31 | 7b,c | Higher is better |
| Behavioral disturbance | |||
| NPI-Question | 0 to 3632 | 832 | Lower is better |
| Combined or global assessments | |||
| CDR-SB | 0 to 1830 | 1 to 230 | Lower is better |
| iADRS | 0 to 146 | 8.8b | Higher is better |
| Dependence scale | 0 to 1533 | 1.5 to 233 | Lower is better |
ADAS-Cog-11 = Alzheimer’s Disease Assessment Scale–Cognitive Subscale-11 items; ADAS-Cog-12 = Alzheimer’s Disease Assessment Scale–Cognitive Subscale-12 items; ADAS-Cog-13 = Alzheimer’s Disease Assessment Scale–Cognitive Subscale-13 items; ADAS-Cog-14 = Alzheimer’s Disease Assessment Scale–Cognitive Subscale-14 items; ADCOMS = Alzheimer’s Disease Composite Score; ADCS-ADL = Alzheimer’s Disease Cooperative Study–Activities of Daily Living; ADCS-ADL-MCI = ADCS-ADL for patients with Mild Cognitive Impairment; CDR-SB = Clinical Dementia Rating–Sum of Boxes scale; DAD = Disability Assessment for Dementia; iADRS = integrated Alzheimer’s Disease Rating Scale; MCID = minimal clinically important difference; MMSE = Mini Mental State Examination; NPI = neuropsychological inventory; SD = standardized difference.
↵a By extension from study of the ADAS-Cog-11.
↵b Estimated as 7% of the total range for the score.
↵c Percentages (not points).