Estimates of the Association Between PrEP Uptake and Incidence of Bacterial STIs
| Model | Bacterial STI, IRR (95% CI) | |||
|---|---|---|---|---|
| Any | Chlamydia | Gonorrheaa | Syphilis | |
| Unadjusted | 3.32 (1.77-6.56) | 2.77 (1.32-5.82) | 7.05 (3.29-15.1) | 1.33 (0.39-4.58) |
| Adjustedb | 2.14 (1.05-4.37) | 1.78 (0.76-4.21) | 4.75 (1.97-11.4) | 0.63 (0.12-3.18) |
| Marginal structuralc | 1.86 (0.86-4.04) | 1.22 (0.53-2.81) | 4.00 (1.67-9.58) | 1.05 (0.28-3.92) |
IRR = incidence rate ratio; PrEP = pre-exposure prophylaxis; STI = sexually transmitted infection.
Note: Estimates are weighted for the inverse probability of treatment. IRRs compare participants with vs without PrEP uptake.
↵a The E-value was 7.46. (This value is specific to the marginal structural model for gonorrhea; it is not for the unadjusted or adjusted model.) The lower confidence limit was 2.73.
↵b Controlled for age, employment, income, access to primary care clinician, alcohol and drug use before sex, and lifetime bacterial STI diagnosis.
↵c Incorporated inverse probability of exposure and attrition weights.