Table 1.

Response to Single Booster Dose of Hepatitis B Vaccine in Previously Vaccinated Military Medical Studentsa

Standard vaccine boosterHeplisav-B booster
Sample sizen = 82n = 160
Years between first series and first anti-HBs titer, mean (SD)21.5 (4.7)21.1 (4.2)
anti-HBs <10 mIU/mLb61
anti-HBs ≥10 mIU/mLb76 (92.7%)159 (99.4%)
Percent difference6.7%
X2 comparison of proportions(95% CI, 1.9%-14.5%); P = .003

  • anti-HBs = hepatitis B surface antigen antibody.

  • ↵a All participants received 3 or 4 doses of standard hepatitis B vaccine before their initial titer.

  • ↵b Follow-up titers drawn ≥30 days after booster vaccine.