Echocardiographic Parameters Stratified by Left Ventricular Ejection Fraction Among Participants in Cohort 1
| Echocardiographic parameter | LVEF ≥50% | LVEF <50% | Total | P Value | |||
|---|---|---|---|---|---|---|---|
| n | Median (Q1, Q3) | n | Median (Q1, Q3) | N | Median (Q1, Q3) | ||
| BMI (kg/m2) | 95 | 27.2 (23.0, 31.8) | 5 | 34.3 (23.4, 38.9) | 100 | 27.2 (23.0, 32.7) | .35 |
| Heart rate | 95 | 76.0 (67.0, 84.0) | 5 | 82.0 (64.0, 85.0) | 100 | 76.0 (66.8, 84.0) | 1.00 |
| LV end-diastolic diameter (mm) | 95 | 44.0 (42.0, 48.0) | 5 | 59.0 (58.0, 65.0) | 100 | 45.0 (42.0, 49.0) | < .001 |
| LV end-systolic diameter (mm) | 95 | 29.0 (26.5, 32.0) | 5 | 52.0 (47.0, 53.0) | 100 | 29.5 (27.0, 32.0) | < .001 |
| Mitral valve E/e` ratioa | 94 | 8.5 (6.7, 10.0) | 4 | 20.0 (12.3, 26.2) | 98 | 8.6 (6.7, 10.7) | .032 |
| Cardiac output (L/min) | 88 | 5.5 (4.7, 6.3) | 5 | 5.2 (4.1, 5.3) | 93 | 5.5 (4.6, 6.3) | .31 |
| Cardiac index (L/min/m2) | 88 | 2.9 (2.6, 3.5) | 5 | 2.6 (2.5, 2.9) | 93 | 2.9 (2.6, 3.4) | .12 |
| LV geometry | 95 | No. (%) | 5 | No. (%) | 100 | No. (%) | < .001 |
| Concentric hypertrophy | 10.0 (10.5) | 0 (0) | 10.0 (10.0) | ||||
| Concentric remodeling | 30.0 (31.6) | 0 (0) | 30.0 (30.0) | ||||
| Eccentric hypertrophy | 3.0 (3.2) | 4.0 (80.0) | 7.0 (7.0) | ||||
| Normal geometry | 52.0 (54.7) | 1.0 (20.0) | 53.0 (53.0) |
BMI = body mass index; LV = left ventricular; LVEF = left ventricular ejection fraction; Q = quartile.
↵a Mitral valve E/e` ratio was calculated as mitral valve early diastolic filling velocity E (meters/second) divided by medial mitral annulus early diastolic velocity by tissue Doppler e’ (meters/second).