Studies Reporting Discontinuation of Antidepressants
| Study, Year (Design) | Duration | Intervention (Cessation Rate) | Comparator (Cessation Rate) | Risk Ratio (95% CI) |
|---|---|---|---|---|
| Depression only (anxiety comorbidities were excluded or not reported) | ||||
| Klein et al,42 2017 (RCT)a | 6 months | CBT + taper (34/85 = 40%) | Maintenance antidepressant medication (n/a) | n/a |
| Huijbers et al,34 2016 (Single arm from RCT)b | 6 months; after 6 months | MBCT-TS (68/128 = 53%; 70/128 = 55%) | n/a | n/a |
| Depression and/or anxiety disorders | ||||
| Eveleigh,27 2015 (RCT)c | 12 months | Letter to primary care clinician with recommendation + tapering advice (4/67 = 6%) | Usual care (6/75 = 8%) | 0.75 (0.22–2.53); 1 study |
| Fava et al,15 1994 (RCT) | 20 weeks | CBT + taper (20/21 = 95%) | Clinical management + taper (20/22 = 91%) | 1.01 (0.89-1.15; I2 = 0%); 2 studies |
| Fava et al,32 1998 (RCT) | 20 weeks | CBT + taper (20/23 = 87%) | Clinical management + taper (20/22 = 91%) | |
| Kuyken et al,16 2008 (RCT)c | 6 months | MBCT-TS (46/61 = 75%) | Maintenance antidepressant medication (n/a) | n/a |
| Kuyken et al,17 2015 (RCT)d | 24 months | MBCT-TS (124/176 = 70%) | Maintenance antidepressant medication (n/a) | n/a |
| Johnson et al,49 2012 (single-arm trial) | Postintervention | Guided primary care clinician review (199/2,849 = 7%) | n/a | n/a |
CBT = cognitive behavioral therapy; ITT = intention to treat; MBCT = mindfulness-based cognitive therapy; MBCT-TS = mindfulness-based cognitive therapy with support to taper; n/a = not applicable; RCT = randomized controlled trial.
↵a A 3-arm RCT, but only 2 arms were relevant for this review; ITT analysis.
↵b A 2-arm RCT, but only 1 arm was relevant for this review (second arm: MBCT + maintenance antidepressant medication); ITT analysis.
↵c ITT analysis.
↵d Per-protocol analysis (completed 4 sessions of MBCT, 83% of those randomized to intervention arm).