Table 2

Performance of the Computerized Adaptive Tests and Brief Questionnaires Relative to the Reference-Standard Clinical Interview

Measure	Test and Value(s)

Screening for MDD	CAD-MDD	PHQ-9	PHQ-2
Sensitivity	0.77	0.75	0.58
Specificity	0.93	0.94	0.93
Positive predictive value	0.57	0.62	0.52
Negative predictive value	0.97	0.97	0.95
AUC (95% CI)	0.85 (0.76-0.94)^a	0.84 (0.75-0.94)^a	0.76 (0.65-0.87)^a
Assessing anxiety severity	CAT-ANX	GAD-7	−

AUC (95% CI)	0.93 (0.90-0.97)^a	0.97 (0.96-0.99)^a	−
OR (95% CI) for 1-point increase in score	1.10 (1.07-1.13)^a	1.58 (1.40-1.80)^a	−
OR (95% CI) for 1-category increase in severity	6.37 (3.72-10.91)^a	11.48 (5.76-22.88)^a	−

AUC = area under the curve; CAD-MDD = Computerized Adaptive Diagnostic Test for Major Depressive Disorder; CAT-ANX = Computerized Adaptive Test–Anxiety Inventory; GAD-7 = Generalized Anxiety Disorder 7-item Scale; MDD = major depressive disorder; OR = odds ratio; PHQ-2 = 2-item Patient Health Questionnaire; PHQ-9 = 9-item Patient Health Questionnaire.
↵a P <.001.