Factorial Analysis: Efficacy of Interventions in Reducing Antibiotic Prescribing at 12 Months
| Measure | No CRP Training (n = 2,360) | CRP Training (n = 2,462) | No Communication Training (n = 2,246) | Communication Training (n = 2,576) |
|---|---|---|---|---|
| Patients prescribed antibiotics, No. (%) | 1,078 (45.7) | 1,097 (44.6) | 1,069 (47.6) | 1,106 (42.9) |
| Basic risk ratio (95% CI) [P value]a | ref | 0.91 (0.77-1.05) [.22] | ref | 0.90 (0.77-1.04) [.17] |
| Fully adjusted risk ratio (95% CI) [P value]b | ref | 0.87 (0.68-1.06) [.18] | ref | 0.81 (0.64-1.00) [.049] |
CRP = C-reactive protein; ref = reference group.
↵a The basic model adjusted for baseline prescribing and clustering by physician and practice.
↵b The fully adjusted model controlled for diagnosis (lower respiratory tract infection, upper respiratory tract infection, pneumonia), sex, age, presence of cough, phlegm, shortness of breath, blocked/runny nose, chest pain, fever, muscle ache, headache, disturbed sleep, feeling generally unwell, interference with social activities, earache, sore throat, facial/sinus pain, crackles, wheeze, pulse >100 beats per minute, temperature >37.8°C, respiratory rate, physician’s rating of severity, low blood pressure, duration of cough, and duration of illness before consultation.