Table 3

Description of the Most Common ADEs Leading to Hospitalization (N = 859 Patients)

Physiologic SystemADEaMain Therapeutic Drug Group Associated With ADESeverity RatingHospital A&E (n = 32), No. (%)Hospital Outpatient (n = 26), No. (%)
Central nervous systemDizziness/unsteadiness on feet/fallsBeta-blocking agents, diuretics, psychoanaleptics, psycholeptics, analgesicsModerate13 (41)3 (12)
GastrointestinalPain in abdomen, diarrheaAnti-inflammatory and antirheumatic products, proton-pump inhibitorsMild11 (34)8 (31)
CardiovascularFaintingBeta-blocking agents, diureticsModerate3 (9)1 (4)
GenitourinaryUp at night to urinate, urinating more or less oftenDiureticsMild2 (6)5 (19)
MusculoskeletalMuscle pain or weaknessSerum lipid–reducing agentsMild03 (12)
  • A&E = accident & emergency department; ADE = adverse drug effect.

  • ↵a ADE is a patient-reported symptom that was established as an ADE per independent clinician review.