Table 3.

Multivariable Models With Vital Signs Predicting Adverse Vascular Events

Outcome Predicted (Subjects)Vital SignPValueRisk Ratio (95% CI)Other Significant Multivariable Predictors*
CI = 95% confidence interval.
* From information available on or before index visit. See text for definitions. Variables are listed in decreasing order of predictive power. Those variables underlined were negatively correlated with risk of the outcome event.
Myocardial infarction (all patients)NonePrevious myocardial infarction, smoker, nitrates, warfarin, diabetes, time treated for hypertension, renal insufficiency, aspirin
First myocardial infarction (patients with no previous infarction)Systolic blood pressure.0161.010 (1.002–1.018)Calcium channel blocker, diabetes, uric acid, African American
Stroke (all patients)Systolic blood pressure.0011.007 (1.003–1.011)Prior stroke, age, weight, aspirin, calcium channel blocker, chronic obstructive pulmonary disease, uric acid, diabetes, renal insufficiency, glucose, previous myocardial infarction or stroke, creatinine clearance (calculated)
First stroke (patients with no previous stroke)Diastolic blood pressure.0051.013 (1.004–1.023)Age, weight, aspirin, chronic obstructive pulmonary disease, diabetes, heart failure, uric acid, creatinine, creatinine clearance (calculated), glucose, renal insufficiency
Myocardial infarction or stroke (all patients)Systolic blood pressure.00151.006 (1.002–1.009)Previous stroke, previous stroke or myocardial infarction, age, aspirin, renal insufficiency, diabetes, smoker, weight, time treated for hypertension, nitrates, chronic obstructive pulmonary disease, glucose
First myocardial infarction or stroke (patients with no previous myocardial infarction or stroke)Systolic blood pressure.0051.007 (1.002–1.012)Age, smoker, chronic obstructive pulmonary disease, diabetes, uric acid, body mass index, renal insufficiency, glucose, warfarin
Ischemic heart disease (patients with no previous ischemic heart disease)Systolic blood pressure.0051.009 (1.003–1.015)Insulin, heart failure, age, oral hypoglycemic drug, African American, peripheral arterial disease
Heart failure (patients with no prior heart failure)Mean blood pressure.0011.012 (1.005–1.020)Age, albumin, insulin, uric acid, chronic obstructive pulmonary disease, previous myocardial infarction, oral hypoglycemic drug, cholesterol, obesity, calcium channel blocker
Chronic renal Insufficiency (patients with no prior chronic renal insufficiency)Systolic blood pressure<.0011.013 (1.006 – 1.021)Creatinine, insulin, albumin, oral hypoglycemic drug, heart failure, glucose, acute renal failure, alcoholism, calcium channel blocker, hemoglobin, peripheral arterial disease
All-cause mortalityHeart rate.0031.016 (1.005–1.026)Age, albumin, heart failure, alcoholism glucose, peripheral arterial disease, renal insufficiency, creatinine, smoker, time treated for hypertension, previous stroke or myocardial infarction, statin antilipemic drug, chronic obstructive pulmonary disease