Table 2.

Continuous Univariable Predictors of Adverse Vascular Events

Coefficients for Univariable Proportional Hazards Regression
VariableMean(SD)MICVAMI or CVAIHDHFCRIDeath
MI = myocardial infarction, CVA = stroke (cerebrovascular accident), IHD = ischemic heart disease, HF = heart failure, CRI = chronic renal insufficiency.
* P ≤.001.
† P ≤.05.
‡ P ≤ 0.01.
Patient characteristics at index visit
Index age (y)57(14)0.023*0.044*0.038*0.021*0.030*0.028*0.053*
Time treated for hypertension (y)5.6(5.6)0.038*0.057*0.051*0.023†0.041*0.034*0.053*
Vital signs from the index visit
Systolic blood pressure (mmHg)143(22)0.0010.007*0.006*0.005†0.009*0.010*0.002
Diastolic blood pressure (mmHg)84(13)−0.011‡−0.006†−0.008*−0.005−0.001−0 .003−0.020*
Heart rate (beats/min)81(10)−0.0030.00043−0.000860.0000550.012‡0.0110.016‡
Mean blood pressure (mmHg)104(14)−0.0050.0030.0020.0020.007‡0.007−0.010‡
Systolic blood pressure × heart rate11,557(2,343)−0.0000010.000048*0.000034‡0.0000360.000095*0.000087*0.000039
Pulse pressure (mmHg)59(18)0.007‡0.013*0.012*0.010*0.013*0.016*0.012*
Pulse pressure × heart rate4,770(1,594)0.000006†0.00012*0.00011*0.00011*0.00016*0.00016*0.00013*
Height (in)65(3)0.027†−0.009−0.0030.0140.0050.0260.017
Weight (lb)192(52)−0.003‡−0.006*−0.005*−0.0010.000530.001−0.006*
Body mass index32(8)−0.020‡−0.035*−0.032*−0.0070.0050.003−0.037*
Laboratory test results available at index visit
Hemoglobin (g/dL) (n = 5,248)13.4(1.6)−0.040−0.046†−0.047‡0.002−0.074‡−0.138*-0.168*
Creatinine (mg/dL) (n = 5,487)1.1(0.6)0.289*0.245*0.252*0.235*0.258*3.540*0.382*
Cholesterol (mg/dL) (n = 5,248)210(47)0.003‡0.002*0.002*0.003‡0.002‡0.001−5.8 3 10−4
Albumin (g/dL) (n = 5,157)4.1(0.4)−0.571*−0.411*−0.446*−0.388‡−0.693*−1.087*−1.066*
Uric acid (mg/dL) (n = 5,172)5.9(1.7)0.100*0.075*0.074*0.075‡0.093*0.207*0.126*
Glucose (mg/dL) (n = 5,475)126(63)0.003*0.002*0.002*0.003*0.003*0.005*0.003*
Potassium (mEq/L) (n = 5,267)4.1(0.4)0.361*0.349*0.335*0.1230.1630.054*0.404*