Intent | Discovery | Application |
Impetus driven by | Current state of knowledge | Needs of end users |
Circumstance | Optional | Often required |
Foundation | Theory-driven | Application-driven |
Philosophy | Naturalism | Pragmatism |
Conduct | Preplanned | Iterative |
Consent | Required | Implied |
Source of data | Multiple organizations | Single organization |
Audience | Multiple organizations | Single organization |
Deviation from usual practice | Significant | Minimal |
Unit of analysis | Patient or clinician | Clinician or practice |
Outcome measures | Study specific/additional | Routinely collected data |
Evaluation criteria | Scientific rigor | Process validity |
Benefit to participants | Little direct benefit to most participants | Direct benefit to most participants |
Level of risk/burden to participants | Higher | Lower |
Timeline | Years | Weeks or months |