Table 1.

Clinical Features of Studies Included for Review

Source	Subjects	Dosage (mg)	Study Duration	Main Outcome Measure	Treatment Arms	Baseline Parameters
bid = twice a day; WHR = waist-to-hip ratio; BMI = body mass index; tid = 3 times a day.
Charles et al,¹² 2000	168 men	850 bid	3 mo	Lipids and blood pressure	2	WHR ≥0.95
Charles et al,¹³ 1998	457 persons	850 bid	1 y	Fibrinolysis	2	WHR ≥0.95 men  WHR ≥ 0.80 women
Fontbonne et al,¹⁴ 1996	108 men  216 women	850 bid	1 y	Metabolic parameters and fat distribution	2	WHR ≥0.95 men  WHR ≥0.80 women
Guigliano et al,¹⁵ 1993	12 women	850 bid	12 wk x 2	Blood pressure and left ventricular mass	2	BMI 34 ± 0.9
Kantola et al,¹⁶ 2002	15 men  8 women	1,500/d	8 wk	Blood pressure and insulin sensitivity	2	Weight 86.4–87.7 kg
Lawson et al,¹⁷ 1970	34 women	250 tid, 500 tid	8 wk x 4	Weight loss	4	Weight 74.5–125.5 kg
Lehtovorta et al,¹⁸ 2001	20 men  20 women	500 bid	6 mo	Metabolic parameters	2	Weight 87.8–91.0 kg
More et al,l¹⁹ 1999	11 women 8 men	850 bid	6 wk x 2	Glucose disposal	2	BMI 30–48.5 kg  Weight 79.0–159.1 kg
Paolisso et al,²⁰ 1998	30 persons	500 bid, 850 bid	15 d	Food intake	2	WHR 0.83 ± 0.01  BMI 33.1 ± 6.4 kg