Results of Clinical Trials Included for Review
| Weight (kg) | BMI (kg/m2) | Waist-Hip Ratio† | ||||
|---|---|---|---|---|---|---|
| Source | Metformin | Placebo | Metformin | Placebo | Metformin | Placebo |
| * Indicates statistically significant (P <.05) difference from baseline. | ||||||
| † A change in ratios cannot be expressed in terms of units. | ||||||
| Charles et al,12 2000 | −0.50 | 0.10 | — | — | −0.008 | −0.015 |
| Charles et al,13 1998 | −2.0 | −0.8 | — | — | — | — |
| Fontbonne et al,14 1996 | −2.0* | −0.8 | — | — | −0.009* | −0.017 |
| Guigliano et al,15 1993 | — | — | 0 | 0 | 0 | 0 |
| Kantola et al,16 2002 | −0.2 | 0.2 | — | — | — | — |
| Lawson et al,17 1970 | −3.6 | −2.22 | — | — | — | — |
| Lehtovorta et al,18 2001 | −2.6 | −1.2 | — | — | — | — |
| More et al,l19 1999 | −0.6 | 0.3 | −0.3 | 0.2 | 0.01 | 0.05 |
| Paolisso et al,20 1998 | −2.8* | −0.25 | −1.0 | −0.5 | 0.2 | 0.25 |