Results of the Meta-Analysis of Randomized Controlled Trials Evaluating Effect of Barley Cholesterol Levels
| Study Type | Total Cholesterol mg/dL (95% CI) | LDL Cholesterol mg/dL (95% CI) | HDL Cholesterol mg/dL (95% CI) | Triglycerides mg/dL (95% CI) |
|---|---|---|---|---|
| CI=confidence interval; LDL = low–density lipoprotein; HDL = high–density lipoprotein; + = analysis-imputed missing studies. | ||||
| Note: All results reported as weighted mean differences. | ||||
| All studies | −13.38 (−18.46 to −8.31) [8 studies] | −10.02 (−14.03 to −6.00) [7 studies] | 0.99 (−0.09 to 2.06) [6 studies] | −11.83 (−20.12 to −3.55) [6 studies] |
| Fixed-effects model | −13.38 (−18.46 to −8.31) [8 studies] | −10.02 (−14.03 to −6.00) [7 studies] | 0.99 (−0.09 to 2.06) [6 studies] | −11.83 (−20.12 to −3.55) [6 studies] |
| Excluding crossover studies | −13.75 (−19.24 to −8.26) [6 studies] | −9.76 (−14.64 to −4.88) [5 studies] | −0.97 (−3.31 to 1.36) [4 studies] | −13.68 (−12.74. 0.39) [4 studies] |
| Excluding studies not double-blind | −17.39 (−26.05 to −8.74) [2 studies] | −13.43 (−20.58 to −6.29) [2 studies] | 0.85 (−4.71 to 6.41) [1 studies] | −22.45 (−50.65 to 5.76) [1 studies] |
| Excluding studies in patients without hypercholesterolemia | −12.56 (−17.89 to −7.24) [6 studies] | −9.38 (−14.13 to −4.63) [5 studies] | 1.08 (−0.01 to 2.17) [4 studies] | −11.06 (−24.97 to 2.85) [4 studies] |
| Trim and fill | −10.49 (−15.09 to −5.89) [+4 studies] | −8.45 (−12.21 to −4.69) [+3 studies] | 1.34 (0.31 to 2.37) [+3 studies] | −11.83 (−20.12 to −3.55) [+0 studies] |
| Studies evaluating barley with diet modification | −17.14 (−25.02 to −9.23) [2 studies] | −14.57 (−21.69 to −17.45) [2 studies] | 1.53 (−2.98 to 6.05) [2 studies] | −17.36 (−40.66 to 5.94) [2 studies] |
| Studies evaluating barley without diet modification | −10.75 (−17.38 to −4.12) [6 studies] | −7.89 (−12.75 to −3.04) [5 studies] | −0.16 (−2.33 to 2.02) [4 studies] | −11.03 (−19.90 to −2.17) [4 studies] |