Table 5.

Validity of the Depression Screens Over Entire Course of Study (N = 506 Women, 45 With Major Depression)

Major DepressionaValidity, % (n/n)
Depression Screen and ResultNoYesTotalSensitivitySpecificityPPVNPV
NPV = negative predictive value; PHQ-2 = 2-item Patient Health Questionnaire; PHQ-9 = 9-item Patient Health Questionnaire; PPV = positive predictive value. Note: Values are numbers of women unless otherwise indicated.
a Women were defined as having major depression if they had a positive result on the Structured Clinical Interview for DSM-IV (SCID).
b Consists of the first 2 questions of the PHQ-9.
c Simple scoring: result is positive if the sum of the numbered responses is ≥10.
d Complex scoring: result is positive if at least 5 symptoms are present, including symptom 1, symptom 2, or both, and each symptom present has a response score of 2 to 3, except for symptom 9, for which a response score of 1 to 3 was acceptable.
2-Question screen (yes/no)100 (45/45)44 (203/461)15 (45/303)100 (203/203)
PHQ-2 (Likert response)b84 (38/45)79 (363/461)28 (38/136)98 (363/370)
PHQ-9 with simple scoringc82 (37/45)84 (386/461)33 (37/112)98 (386/394)
PHQ-9 with complex scoringd67 (30/45)92 (422/461)43 (30/69)97 (422/437)