Validity of the Depression Screens Over Entire Course of Study (N = 506 Women, 45 With Major Depression)
| Major Depressiona | Validity, % (n/n) | ||||||
|---|---|---|---|---|---|---|---|
| Depression Screen and Result | No | Yes | Total | Sensitivity | Specificity | PPV | NPV |
| NPV = negative predictive value; PHQ-2 = 2-item Patient Health Questionnaire; PHQ-9 = 9-item Patient Health Questionnaire; PPV = positive predictive value. Note: Values are numbers of women unless otherwise indicated. | |||||||
| a Women were defined as having major depression if they had a positive result on the Structured Clinical Interview for DSM-IV (SCID). | |||||||
| b Consists of the first 2 questions of the PHQ-9. | |||||||
| c Simple scoring: result is positive if the sum of the numbered responses is ≥10. | |||||||
| d Complex scoring: result is positive if at least 5 symptoms are present, including symptom 1, symptom 2, or both, and each symptom present has a response score of 2 to 3, except for symptom 9, for which a response score of 1 to 3 was acceptable. | |||||||
| 2-Question screen (yes/no) | 100 (45/45) | 44 (203/461) | 15 (45/303) | 100 (203/203) | |||
| Negative | 203 | 0 | 203 | ||||
| Positive | 258 | 45 | 303 | ||||
| Total | 461 | 45 | 506 | ||||
| PHQ-2 (Likert response)b | 84 (38/45) | 79 (363/461) | 28 (38/136) | 98 (363/370) | |||
| Negative | 363 | 7 | 370 | ||||
| Positive | 98 | 38 | 136 | ||||
| Total | 461 | 45 | 506 | ||||
| PHQ-9 with simple scoringc | 82 (37/45) | 84 (386/461) | 33 (37/112) | 98 (386/394) | |||
| Negative | 386 | 8 | 394 | ||||
| Positive | 75 | 37 | 112 | ||||
| Total | 461 | 45 | 506 | ||||
| PHQ-9 with complex scoringd | 67 (30/45) | 92 (422/461) | 43 (30/69) | 97 (422/437) | |||
| Negative | 422 | 15 | 437 | ||||
| Positive | 39 | 30 | 69 | ||||
| Total | 461 | 45 | 506 | ||||