Methodologic Quality of Included Studies
| Study (Year) | Allocation Concealment | Randomization | Comparability of Groups at Baseline | Blindinga | Provision of Care Apart From the Intervention | Percentage Participation |
|---|---|---|---|---|---|---|
| Williamson et al14 (2007) | Adequate | Random number table, block randomization | Comparable | Double blind | Equal | 86 |
| Meltzer et al17 (2005) | Adequate | Computer-generated randomization stratified by duration of symptoms at presentation | Comparable | Double blind | Equal | 90 |
| Nayak et al18 (2002) | Adequate: matching placebo used | Randomized, method not reported | Comparable | Double blind | Equal | 89 |
| Dolor et al20 (2001) | Adequate | Permuted block randomization scheme stratified by site | Comparable | Double blind | Equal | 94 |
| Meltzer et al21 (2000) | Adequate: matching placebo used | Randomized, method not reported | Comparable | Double blind | Equal | 100 |
| Barlan et al19 (1997) | Adequate | Randomized, method not reported | Comparable | Double blind | Equal | 59 |
↵a Williamson et al was the only study to specifically describe the method of double blinding.