Rate of Treatment Adjustment (Number of Adjustments Over 12 Months)
| Therapeutic Class | Rate (95% CI) | Relative Ratea (95% CI) | |
|---|---|---|---|
| Intervention | Usual Care | ||
| Antidepressant | 3.37 (2.92–3.89) | 0.53 (0.34–0.82) | 6.20b (3.88–9.90) |
| Insulin | 3.26 (2.43–4.36) | 1.02 (0.67–1.55) | 2.97b (1.83–4.83) |
| Oral hypoglycemic | 0.62 (0.44–0.88) | 0.34 (0.23–0.50) | 1.80c (1.07–3.01) |
| Antihypertensive | 2.33 (1.86–2.92) | 1.11 (0.81–1.51) | 1.86b (1.28–2.71) |
| Lipid lowering | 0.81 (0.64–1.03) | 0.55 (0.42–0.72) | 1.56c (1.10–2.20) |
Note: Treatment adjustment defined as (1) an increase in the number of medication classes prescribed, (2) a change in dosage of at least 1 ongoing medication class, (3) a switch to a medication in a different class, or (4) a switch to a different medication within the same class over the 12-month intervention period. Medication adjustment includes initiations and subsequent treatment changes.
↵a Adjusted for baseline Poisson regressions with robust (Huber-White) standard errors predicting the rate of adjustments (baseline to 12 months) within each therapeutic class.
↵b P value <.001.
↵c P value <.05.