Table 4

Change in the WOMAC Composite and Subscale Scores Over Time

ScoreWeek 5Week 9Week 12Week 24Week 52
WOMAC composite score change, mean (SE)
Dextrose7.94 (3.21)13.91 (3.23)a13.31 (3.32)b15.85 (3.26)a15.32 (3.32)a
Saline5.22 (3.21)6.75 (3.27)a8.19 (3.37)b8.12 (3.33)a7.59 (3.36)a
Exercise4.42 (3.21)2.51 (3.26)a4.26 (3.36)b8.48 (3.28)a8.24 (3.33)a
Subscale score change, mean (SE)
Pain
Dextrose8.17 (3.49)14.00 (3.52)a11.78 (3.62)b15.50 (3.56)a14.18 (3.62)
Saline3.28 (3.50)5.29 (3.56)a5.79 (3.67)b6.40 (3.63)a7.38 (3.67)
Exercise4.53 (3.51)3.44 (3.55)a4.89 (3.66)b8.07 (3.60)a9.24 (3.63)
Stiffness
Dextrose7.08 (4.50)14.17 (4.53)c13.49 (4.67)b14.85 (4.58)15.55 (4.66)
Saline8.62 (4.51)9.12 (4.59)c12.22 (4.73)b10.40 (4.67)9.97 (4.72)
Exercise3.63 (4.51)0.14 (4.58)c3.13 (4.71)b8.18 (4.61)8.31 (4.68)
Function
Dextrose8.57 (3.27)13.58 (3.30)a14.61 (3.40)a17.19 (3.33)a16.25 (3.39)a
Saline3.77 (3.28)5.85 (3.34)a6.63 (3.44)a7.62 (3.40)a5.46 (3.44)a
Exercise5.10 (3.28)4.00 (3.33)a4.89 (3.43)a9.30 (3.35)a7.31 (3.40)a
• WOMAC = Western Ontario McMaster University Osteoarthritis Index.

• Notes: Numbers of participants for measurement points are as follows. Week 5: n = 30 dextrose, n = 29 saline, n = 28 exercise. Week 9: n = 30 dextrose, n = 26 saline, n = 27 exercise. Week 12: n = 27 dextrose, n = 24 saline, n = 25 exercise. Week 24: n = 28 dextrose, n = 25 saline, n = 27 exercise. Week 52: n = 26 dextrose, n = 25 saline, n = 26 exercise. Repeated measures analysis of variance compared between-group total and subscale WOMAC scores after adjusting for baseline scores, age, sex, and body mass index.

• a Dextrose outperformed saline (P <.05) and exercise (P <.05); no statistically significant differences between saline and exercise.

• b Dextrose outperformed exercise (P <.05); no statistically significant differences between dextrose and saline, and between saline and exercise.

• c Dextrose outperformed exercise (P <.05); saline outperformed exercise (P <.05); no statistically significant differences between dextrose and saline.