Table 3

Events After Diagnosis of Type 2 Diabetes for Opportunistic Targeted Screening (n = 359) and Clinical Diagnosis (n = 206) Groups

	Incidence, No. (%)
Events	Opportunistic Targeted Screening	Clinical Diagnosis	P Value	Unadjusted HR (95% CI)^a	P Value	Adjusted HR (95% CI)^a	P Value
Primary outcomes
Major macrovascular event^b	34 (9.5)	21 (10.2)	.78	0.84 (0.49-1.44)	.52	0.67 (0.36-1.25)	.21
CVD death	16 (4.5)	4 (1.9)	.16	2.10 (0.70-6.28)	.19	1.88 (0.41-8.57)	.42
Nonfatal MI	11 (3.1)	11 (5.3)	.18	0.54 (0.23-1.25)	.15	0.43 (0.18-1.02)	.06
Nonfatal stroke	10 (2.8)	9 (4.4)	.32	0.57 (0.23-1.40)	.22	0.68 (0.23-2.02)	.49
Secondary outcomes
Microvascular event^b	54 (17.1)	24 (15.2)	.59	1.04 (0.64-1.68)	.88	0.94 (0.55-1.60)	.81
Retinopathy	5 (1.5)	7 (3.9)	.08	0.32 (0.10-1.01)	.05	0.75 (0.19-3.08)	.69
Neuropathy	40 (11.5)	16 (8.3)	.25	1.33 (0.74-2.37 )	.34	1.23 ( 0.63 -2.39)	.54
Nephropathy	18 (5.5)	10 (5.9)	.87	0.86 (0.39-1.85)	.69	0.93 (0.38-2.24)	.87
Any first CVD^c	68 (18.9)	28 (13.6)	.10	1.33 (0.86-2.07)	.21	1.03 (0.63-1.67)	.92
All-cause death	31 (8.6)	22 (10.7)	.42	0.73 (0.42-1.26)	.26	0.60 (0.31-1.13)	.12
Non-CVD death	15 (4.2)	18 (8.7)	.03	0.43 (0.22-0.85)	.02	0.33 (0.15-0.71)	.01

CVD = cardiovascular disease; HR = hazard ratio; MI = myocardial infarction.
↵a Hazard ratios with matching P values compare hazards in type 2 diabetes detected by opportunistic targeted screening with those in clinically diagnosed type 2 diabetes, unadjusted and adjusted for age, sex, and the following baseline characteristics: CVD, systolic blood pressure, fasting plasma glucose, and plasma creatinine.
↵b Some patients had multiple events.
↵c Nonfatal MI, nonfatal stroke, heart failure, ischemic heart disease, transient cerebral ischemia, or peripheral arterial disease.