Anticoagulation Outcomes at 7 Months
| Outcome | Morning | Evening | Difference | P Value | 95% CI for Difference |
|---|---|---|---|---|---|
| Primary outcome | |||||
| Percent change in proportion of time outside target INR range, median (IQR) | –11.9 (–59.5 to 65.6) | –22.9 (–62.5 to 77.4) | 4.4a | .62 | –17.6 to 27.3 |
| Secondary outcomes | |||||
| Absolute change in TTR, % | 2.9 (22.1) | 3.0 (22.7) | –0.1 | .97 | –6.1 to 5.9 |
| Percent of patients with TTR >75% | 56.0 | 54.6 | 1.4 | .89 | –12.3 to 14.9 |
| Percent of patients with TTR <60% | 22.0 | 22.2 | –0.2 | .99 | –11.5 to 11.9 |
| Maximum out-of-range INR, median (IQR) | 3.6 (3.3-4.0) | 3.6 (3.4-4.0) | 0.0a | .52 | –0.2 to 0.1 |
| Minimum out-of-range INR, median (IQR) | 1.6 (1.3-1.8) | 1.7 (1.5-1.8) | –0.1a | .15 | –0.2 to 0.0 |
| Percent of INR values above range, median (IQR) | 10.0 (0-20.0) | 11.1 (0-19.7) | 0.0a | .90 | –1.8 to 1.4 |
| Percent of INR values below range, median (IQR) | 15.0 (0-28.6) | 12.8 (0-22.6) | 0.0a | .48 | –0.5 to 4.3 |
INR = international normalized ratio; IQR = interquartile range; TTR = time within therapeutic range.
↵a The difference in medians is by Hodges–Lehmann estimation; hence, value differs from a simple subtraction of the group medians provided.