Table 1

Overview of Antidepressant Medications Tested in the Included Trials and in the Meta-Analysis

Medication ClassTrial Groups/Arms and Specific Medication Tested
TCA, tricyclic and tetracyclic antidepressants40 Separate groups in trials, after pooling of groups in studies with more than 1 TCA, 37 arms in analyses
 14 Amitriptyline (1 pooling of 2 groups with different dosages, 1 pooled with dothiepin)
 8 Imipramine (1 pooled with desipramine)
 8 Dothiepin/dosulepin (1 pooled with amitriptyline)
 3 Clomipramine
 1 Amineptine
 1 Desipramine (pooled with imipramine)
 1 Doxepin
 1 Lofepramine
 1 Maprotiline
 1 Tianeptine
 1 Individualized TCA
SSRI, selective serotonin reuptake inhibitors38 Arms in total, 37 after pooling of 2 arms in a study with 2 SSRI 35 arms
 12 Paroxetine
 9 Fluoxetine
 5 Sertraline
 5 Citalopram (1 pooled with escitalopram)
 2 Fluvoxamine
 3 Escitalopram (1 pooled with citalopram)
 1 Individualized SSRI
SNRI, serotonin-noradrenaline reuptake inhibitor6 Arms in total
 6 Venlafaxine
NRI, noradrenaline reuptake inhibitor1 Arm in total
 1 Reboxetine
SARI, serotonin (5-HT2) antagonists and reuptake inhibitor5 Arms in total
 5 Trazodone
NaSSA, noradrenergic and specific serotonergic antidepressive agents9 Arms in total
 8 Mianserin (2 underdosing)
 1 Mirtazapine
rMAO-A, reversible inhibitors of monoaminoxidase A8 Arms in total, 6 in analyses
 4 Moclobemide,
 4 Minaprine (2 pooling of different dosages)
Hypericum, extracts from Hypericum perforatum L. (St. John’s wort)15 Arms in total, 14 after pooling of 2 arms testing different extracts in 1 study; 12 different extracts