Overview of Antidepressant Medications Tested in the Included Trials and in the Meta-Analysis
| Medication Class | Trial Groups/Arms and Specific Medication Tested |
|---|---|
| TCA, tricyclic and tetracyclic antidepressants | 40 Separate groups in trials, after pooling of groups in studies with more than 1 TCA, 37 arms in analyses |
| 14 Amitriptyline (1 pooling of 2 groups with different dosages, 1 pooled with dothiepin) | |
| 8 Imipramine (1 pooled with desipramine) | |
| 8 Dothiepin/dosulepin (1 pooled with amitriptyline) | |
| 3 Clomipramine | |
| 1 Amineptine | |
| 1 Desipramine (pooled with imipramine) | |
| 1 Doxepin | |
| 1 Lofepramine | |
| 1 Maprotiline | |
| 1 Tianeptine | |
| 1 Individualized TCA | |
| SSRI, selective serotonin reuptake inhibitors | 38 Arms in total, 37 after pooling of 2 arms in a study with 2 SSRI 35 arms |
| 12 Paroxetine | |
| 9 Fluoxetine | |
| 5 Sertraline | |
| 5 Citalopram (1 pooled with escitalopram) | |
| 2 Fluvoxamine | |
| 3 Escitalopram (1 pooled with citalopram) | |
| 1 Individualized SSRI | |
| SNRI, serotonin-noradrenaline reuptake inhibitor | 6 Arms in total 6 Venlafaxine |
| NRI, noradrenaline reuptake inhibitor | 1 Arm in total 1 Reboxetine |
| SARI, serotonin (5-HT2) antagonists and reuptake inhibitor | 5 Arms in total 5 Trazodone |
| NaSSA, noradrenergic and specific serotonergic antidepressive agents | 9 Arms in total 8 Mianserin (2 underdosing) 1 Mirtazapine |
| rMAO-A, reversible inhibitors of monoaminoxidase A | 8 Arms in total, 6 in analyses 4 Moclobemide, 4 Minaprine (2 pooling of different dosages) |
| Hypericum, extracts from Hypericum perforatum L. (St. John’s wort) | 15 Arms in total, 14 after pooling of 2 arms testing different extracts in 1 study; 12 different extracts |