Intention-to-Treat Analysis of Secondary Outcomes
| Outcome | Intervention Group | Control Group | Adjusteda Odds Ratio or Mean Difference (95% CI) | P Value |
|---|---|---|---|---|
| Drug-specific outcomes | ||||
| Proton pump inhibitor, No. (%) | ||||
| Baseline | 53 (53.5) | 65 (67.7) | ||
| Intervention completion | 23 (23.2) | 46 (47.4) | 0.30 (0.14–0.68) | .04 |
| Duplicate, No. (%) | ||||
| Baseline | 19 (19.2) | 13 (13.5) | ||
| Intervention completion | 11 (11.1) | 11 (11.3) | 0.83 (0.32–2.13) | .99 |
| Long-term benzodiazepines, | ||||
| No. (%) | ||||
| Baseline | 14 (14.1) | 8 (8.1) | ||
| Intervention completion | 9 (9.1) | 9 (9.1) | 1.31 (0.47–3.68) | .99 |
| Patient-reported outcomes | ||||
| WBQ-12 score: mean well-beingb | ||||
| Baseline | 24.3 | 24.4 | ||
| Intervention completion | 23.6 | 24.0 | –0.41 (−0.80 to 1.07) | .99 |
| BMQ score: median necessity-concern differentialc | ||||
| Baseline | 7.0 | 5.8 | ||
| Intervention completion | 6.0 | 6.0 | 0.16 (−1.85 to 1.07) | .99 |
BMQ = Beliefs About Medicine Questionnaire; WBQ-12 = 12-item Well-Being Questionnaire.
Note: Figures are numbers (percentages) unless stated otherwise. The Bonferroni method was used to account for multiple comparisons.
↵a Adjusted for age, sex, baseline number of PIP drugs, baseline number of repeat medications, number of general practitioners, and practice location.
↵b Well-being score ranges from 0 to 36 (1–12 low, 13–24 medium, 25–36 high).
↵c Scale from −20 to 20, where positive scores indicate benefits outweigh risks.