Table 1

The Systematic Review Question Design According to the PRISMA Guidelines¹⁹

Population	Intervention	Comparison	Outcomes	Study Design
Main concept
Primary care practitioners Primary care patients	Cancer risk assessment tool to determine a primary care patient’s individual risk of cancer	Standard clinical care	Clinicians Clinical outcomes including appropriate referral behavior Patterns and accuracy of risk perception Cancer knowledge Frequency of use Acceptability by physicians Confidence of use by clinicians Attitudes to the tool Patients Patient cancer anxiety/worry Acceptability by patients Patient behavior including uptake of secondary referral behavior Adherence to screening recommendations Intention to undergo screening Satisfaction with consultation	Randomized controlled trials
Synonyms/search terms
Primary care Primary care clinicians Primary care physicians Family practice General practice GPs Patients	Risk-assessment tool Clinical tool Risk-prediction tool Decision-support tool Risk-assessment model Computer decision-support tool Adult population Cancer Family history [and synonyms for family]	Standard care Usual care	Acceptability Effectiveness Frequency of use Referral data Appropriateness of management Risk accuracy Patient risk perception Psychosocial outcomes Cancer worry Patient behavior	–

GP = general practitioner; PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses.