Effect of Oral and Topical Antibiotics on Subjective and Objective Eczema Severity at 2 Weeks, 4 Weeks, and 3 Months
| Outcome | Control | Oral Antibiotic | Topical Antibiotic | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Baseline, Mean (SD) | Follow-up, Mean (SD) | N | Baseline, Mean (SD) | Follow-up, Mean (SD) | Intervention Effect (95% CI) | N | Baseline, Mean (SD) | Follow-up, Mean (SD) | Intervention Effect (95% CI) | |
| POEM | |||||||||||
| 2 weeksa | 36 | 13.4 (5.1) | 6.2 (6.0) | 34 | 14.6 (5.3) | 8.3 (7.3) | 1.5 (−1.4, 4.4) | 31 | 16.9 (5.5) | 9.3 (6.2) | 1.5 (−1.6, 4.5) |
| 4 weeks | 35 | 13.6 (5.0) | 8.0 (6.0) | 33 | 14.6 (5.4) | 8.4 (7.7) | −0.2 (−3.1, 2.8) | 30 | 16.6 (5.4) | 9.5 (5.9) | 0.0 (−3.1, 3.1) |
| 3 months | 25 | 13.7 (5.1) | 7.7 (5.5) | 28 | 14.4 (5.7) | 7.8 (6.1) | −0.2 (−3.1, 2.7) | 21 | 16.4 (5.5) | 7.9 (5.6) | −1.1 (−4.3, 2.1) |
| EASI | |||||||||||
| 2 weeks | 34 | 5.8 (5.0) | 2.5 (5.6) | 34 | 7.3 (6.1) | 3.1 (3.6) | 0.2 (−0.1, 0.5) | 31 | 9.5 (9.7) | 4.9 (5.6) | 0.4 (0.1, 0.8) |
| weeks | 34 | 5.8 (5.0) | 4.0 (6.6) | 33 | 7.4 (6.2) | 3.2 (3.8) | −0.1 (−0.5, 0.2) | 30 | 9.7 (9.8) | 5.0 (6.9) | 0.0 (−0.3, 0.4) |
EASI = Eczema Area and Severity Index (objective eczema severity); POEM = Patient Oriented Eczema Measure (subjective eczema severity).
↵a Primary outcome.