Adjusted Hazard of Receiving an Allopurinol Prescription
| Hazard Ratio | 95% CI | |
|---|---|---|
| Eligible for allopurinol (ever) | ||
| Not eligible | 1 [referent] | 1 [referent] |
| CKD | 3.48 | 2.31–5.26 |
| Diuretic therapy | 2.49 | 2.10–2.94 |
| ≥2 Consultations for gout in 12 months | 3.88 | 3.22–4.68 |
| Tophi | 2.10 | 1.10–4.00 |
| Urolithiasis | 2.33 | 1.44–3.78 |
| Age at diagnosis of gouta | 1.00 | 0.99–1.01 |
| Male | 0.59 | 0.51–0.69 |
| Overweight (BMI >25kg/mb) | ||
| Not overweight (BMI ≤25kg/mb) | 1 [reference] | 1 [reference] |
| Overweight | 1.14 | 1.02–1.27 |
| Not recorded | 0.88 | 0.74–1.04 |
| Exposure to alcohol | ||
| Never exposed | 1 [reference] | 1 [reference] |
| Ever exposed to alcohol | 1.07 | 0.93–1.24 |
| Not recorded | 0.80 | 0.65–0.99 |
| Charlson comorbidity scorea | 0.84 | 0.81–0.88 |
| Number of consultations for gouta (during entire follow-up) | 1.05 | 1.02–1.08 |
| Number of consultations for any reason (during entire follow-up) | ||
| Quartile 1 (0–34) | 1 [reference] | 1 [reference] |
| Quartile 2 (34–64) | 0.44 | 0.37–0.61 |
| Quartile 3 (65–119) | 0.20 | 0.16–0.24 |
| Quartile 4 (≥120) | 0.07 | 0.05–0.09 |
| Time-varying covariatesc | ||
| Male | 1.007 | 1.004–1.011 |
| Number of consultations for gouta (during entire follow-up) | 1.002 | 1.001–1.002 |
| Number of consultations for any reason (during entire follow-up) | ||
| Quartile 1 (0–34) | 1 [reference] | 1 [reference] |
| Quartile 2 (34–64) | 1.005 | 1.001–1.009 |
| Quartile 3 (65–119) | 1.009 | 1.005–1.037 |
| Quartile 4 (≥120) | 1.015 | 1.012–1.020 |
| Eligible for allopurinol (ever) | ||
| Not eligible | 1 [referent] | 1 [referent] |
| CKD | 0.990 | 0.982–0.999 |
| Diuretic therapy | 0.991 | 0.988–0.994 |
| ≥2 consultations for gout in 12 mo | 0.985 | 0.980–0.989 |
| Tophi | 0.994 | 0.979–1.008 |
| Urolithiasis | 0.990 | 0.982–0.999 |
ACR = American College of Rheumatology; BMI = body mass index; CKD = chronic kidney disease; EULAR = European League Against Rheumatism.
Note: Model is adjusted for all listed variables and clustering by practice.
↵a Denotes a continuous variable.
↵b Eligibility according to the EULAR and ACR guidelines.5,6