Comparison of Age Groups, Medications, and Medical Conditions of Cases and Controls
| Case | Control | P valuea | |
|---|---|---|---|
| Age Group | |||
| 60-64 | 26 | 27 | .86 |
| 65-69 | 20 | 18 | .70 |
| 70-74 | 9 | 13 | .35 |
| 75-79 | 13 | 9 | .35 |
| ≥80 | 2 | 3 | .65 |
| Medication | |||
| No medication | 15 | 13 | .70 |
| Anti hypertensive drugs | |||
| Thiazides | 2 | 4 | .69 |
| Calcium channel blockers | 10 | 8 | .63 |
| Beta-blockers | 20 | 13 | .21 |
| Loop diuretics | 2 | 3 | 1 |
| ACE/ARBs | 18 | 11 | .19 |
| Potassium-sparing diuretics | 2 | 4 | .69 |
| Centrally-acting agents | 3 | 2 | 1 |
| Association ACE/ARBs + thiazides | 11 | 12 | .82 |
| Association ACE/ARBs + CCBs | 5 | 2 | .45 |
| Association beta-blockers + thiazides | 0 | 3 | .25 |
| Lipid lowering drugs | |||
| Statin | 22 | 23 | 88 |
| Ezetrol | 0 | 0 | |
| Inhalated medication | |||
| Beta-mimetics | 3 | 4 | 1 |
| Anti-leukotriene | 1 | 1 | 1 |
| Medication (continued) | |||
| Others | |||
| Bisphosphonates | 0 | 1 | 1 |
| Anti-epileptic drug | 0 | 1 | 1 |
| NSAIDs | 1 | 0 | 1 |
| Proton pump inhibitor | 11 | 11 | 1 |
| Alpha-blocker | 3 | 0 | .25 |
| Melatonin | 0 | 0 | |
| Progestogen | 1 | 0 | 1 |
| Selective estrogen receptor modulator | 0 | 0 | |
| GnRH analogue | 0 | 0 | |
| Others | 88 | 92 | .75 |
| Medical Conditions | |||
| Hypertension | 51 | 49 | .71 |
| Severe arteriopathy | 2 | 1 | 1 |
| Severe venous insufficiency | 4 | 2 | .68 |
| Diabetes | 14 | 12 | .66 |
| Hypothyroidy | 9 | 7 | .60 |
| Hypoparathyroidy | 0 | 1 | 1 |
| Severe renal insufficiency | 6 | 1 | .11 |
| Peripheral neuropathy | 3 | 0 | .24 |
| Restless leg syndrome | 1 | 0 | 1 |
| Alcohol addiction | 0 | 2 | .50 |
| Cancer (not in remission) | 2 | 2 | 1 |
| Others | 55 | 59 | .38 |
ACE = angiotensin-converting enzyme; ARB = angiotensin II receptor blocker; CCB = calcium channel blocker; GnRH = gonadatrophin-releasing hormone; NSAID = non-steroidal anti-inflammatory drug.
↵a P value were calculated using a χ2 test.