Table 1

Top POEM for Each Year From 1998 to 2017

YearTitle of POEMReference
1998Metformin is best for obese patients with type 2 diabetes mellitusUK Prospective Diabetes Study Group10
1999β-Blockers are effective in heart failureLechat P, et al11
20003 Years between Papanicolaou tests are adequate for many womenSawaya GF, et al12
2001Managing heart rate and rhythm are similar for atrial fibrillationHohnloser SH, et al13
2002Hormone replacement overall is not beneficialWriting Group for the Women’s Health Initiative Investigators14
2003Self-breast examination does not reduce mortalityThomas DB, et al15
2004Breast cancer screening results in overdiagnosisZahl P, et al16
2005Vaccine prevents human papillomavirus infectionHarper DM, et al17
2006Delayed prescription for acute otitis media reduces unnecessary antibioticsSpiro DM, et al18
2007Home blood glucose monitoring is ineffective for type 2 diabetes mellitusFarmer A, et al19
2008Intensive control of blood glucose in type 2 diabetes mellitus may be harmfulGerstein HC, et al20
2009Prostate-specific antigen screening does not reduce mortality from prostate cancerAndriole GL, et al21
2010Statin + fenofibrate is no better than statin alone in type 2 diabetes mellitusThe ACCORD Study Group22
2011Rivaroxaban is similar to warfarin for patients with nonvalvular atrial fibrillationPatel MR, et al23
2012Conservative therapy with antibiotics is an option for early uncomplicated acute appendicitisVaradhan KK, et al24
2013Fasting is not necessary before measuring lipid panelsSidhu D and Naugler C25
2014Niacin does not improve clinical outcomes in patients with vascular diseaseThe HPS2-THRIVE Collaborative Group, Landray MJ, et al26
2015Steroids are beneficial as adjunctive treatment for community-acquired pneumoniaSiemieniuk RAC, et al27
2016Active surveillance for localized prostate cancer: no increased mortality, but higher rates of clinical progressionHamdy FC, et al28
2017Semaglutide reduces cardiovascular events in high-risk patients with type 2 diabetes mellitusMarso SP, et al29
  • POEM = patient-oriented evidence that matters.