Results of Group Effect on WOMAC Pain Score Using Analysis of Covariance
| Analysis Performed | Intervention Group (n = 104), mean (SD) | Control Group (n = 104), mean (SD) | Model 1 | Model 2a | ||||
|---|---|---|---|---|---|---|---|---|
| Between-Group Difference (95% CI) | P Value | SE | Between-Group Difference (95% CI) | P Value | SE | |||
| ITT analysis | ||||||||
| Week 0 | 46.2 (21.6) | 47.7 (19.8) | ||||||
| Week 24 | 28.8 (23.4) | 44.3 (22.3) | –15.5(–21.9 to – 9.0) | <.001 | 3.3 | –15.6(–20.5 to – 10.7) | <.001 | 2.5 |
| Per–protocol analysisb | ||||||||
| Week 0 | 47.6 (21.3) | 47.6 (19.7) | ||||||
| Week 24 | 29.4 (23.3) | 44.3 (22.3) | –14.9(–21.4 to – 8.4) | <.001 | 3.3 | –16.0(–21.0 to – 11.0) | <.001 | 2.6 |
| Imputed data analysis | ||||||||
| Week 0 | 46.2 (21.6) | 47.7 (19.8) | ||||||
| Week 24 | 28.9 (24.1) | 44.6 (22.8) | –15.8(–22.2 to – 9.3) | <.001 | 3.3 | –14.9(–20.1 to – 9.8) | <.001 | 2.6 |
| Per–protocol analysis with imputationb | ||||||||
| Week 0 | 47.6 (21.3) | 47.6 (19.7) | ||||||
| Week 24 | 29.5 (23.3) | 44.8 (22.4) | –15.3 (–21.9 to – 8.7) | <.001 | 3.3 | –15.8 (–20.9 to – 10.7) | <.001 | 2.6 |
ITT = intention–to–treat; SD = standard deviation; SE = standard error; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index.
↵a Adjusted for baseline score, duration of knee pain, number of comorbidities, bilateral knee pain status (yes or no), total amount of analgesic consumption, and age.
↵b Included participants who attended all 3 sessions.