Chest
Clinical InvestigationsA Prospective Study of the Natural History of Asthma: Remission and Relapse Rates
Section snippets
MATERIALS AND METHODS
The population under study is a random stratified cluster sample of non-Mexican white American households in Tucson, Ariz. Details of the selection of the population and general methods have been published.15 Initial self-completion questionnaires were obtained from 3, 454 subjects. The present study examined only those who completed questionnaires in the first (1972 to 1973) and seventh (1981 to 1983) surveys. Because the surveys take slightly longer than one year, the mean follow-up was 9.4
Remission of Asthma
Of the 2, 300 subjects in the study, 136 had active asthma in the first survey. In the seventh survey, 30 of these 136 subjects were in remission, a 22 percent remission rate.
Figure 1 shows the rate of remission of active asthma by the age of the subjects at entry into the study. The total number at risk for a remission in each decade of age is indicated at the bottom of Figure 1. The remission rate was highest in the group aged 10 to 19 years, with 65 percent (13/20) having a remission, and
DISCUSSION
In this study, a high remission rate (65 percent; 13/20) was noted only in the group aged 10 to 19 years. Previous studies have also shown this decade to be characterized by frequent remissions. Williams and McNicol and associates7, 8, 9, 10 prospectively studied 331 children from 7 to 21 years old who had asthma or wheezy bronchitis when enrolled. Remissions of at least one-year duration were noted in 70 to 75 percent of these children at the age of 14 years, and 55 percent of those who had a
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Supported by Specialized Center of Research grant HL-14136 from the National Heart Lung, and Blood Institute.
†American Thoracic Society/American Lung Association Research Training Fellowship awardee at the time of the study