Impact of recommendations to suspend the birth dose of hepatitis B virus vaccine

JAMA. 2001 Apr 11;285(14):1874-9. doi: 10.1001/jama.285.14.1874.

Abstract

Context: In July 1999, due to concerns about thimerosal content, the American Academy of Pediatrics (AAP) and the Public Health Service (PHS) recommended suspending hepatitis B virus (HBV) vaccination at birth except for mothers who had positive or unknown hepatitis B surface antigen (HBsAg) status. In September 1999, the Centers for Disease Control and Prevention recommended that hospitals resume HBV vaccination at birth with a new thimerosal-free vaccine. Whether the 2 changes in recommendations within 3 months led to less-than-optimal compliance in hospital nurseries is unknown.

Objective: To determine hospital HBV vaccination policy before the recommendation for delay of HBV vaccination and 1 year later.

Design, setting, and participants: Survey of all 46 hospitals with obstetric services and neonatal nurseries in Cook County, Illinois.

Main outcome measures: Hepatitis B virus immunization practices before July 1999 and in August 2000; hospital factors associated with routine HBV immunization and compliance with AAP and PHS recommendations.

Results: Before July 1999, 74% of surveyed hospital nurseries offered HBV vaccine to all neonates; only 39% did so in August 2000. Being located in the Chicago city limits (88% vs 57%; P =.02) and having an academic affiliation (93% vs 66%; P =.05) were positively associated with routine neonatal immunization before July 1999. Both academic affiliation and city location were associated with routine immunization in August 2000 (71% vs 25% [P =.003] and 60% vs 14% [P =.002], respectively) and with compliance with recommendations for suspension (57% vs 25% [P =.03] and 56% vs 10% [P =.001]).

Conclusions: We documented a 35% decrease in hospital nurseries that routinely offered HBV immunization 1 year after the AAP and PHS recommendations were made. Special efforts may be required to make at-birth administration of HBV vaccination universal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Guideline Adherence*
  • Hepatitis B Vaccines / administration & dosage*
  • Humans
  • Illinois
  • Infant, Newborn
  • Nurseries, Hospital / standards*
  • Practice Guidelines as Topic*
  • Preservatives, Pharmaceutical
  • Thimerosal
  • Vaccination / standards*

Substances

  • Hepatitis B Vaccines
  • Preservatives, Pharmaceutical
  • Thimerosal