Comparing patterns of long-term benzodiazepine use between a Dutch and a Swedish community

Pharmacoepidemiol Drug Saf. 2003 Jan-Feb;12(1):49-53. doi: 10.1002/pds.784.

Abstract

Background: There is much concern about the widespread long-term use of benzodiazepines. Utilisation data can give a foundation for interventions for appropriate use.

Objective: To compare long-term usage patterns of benzodiazepines in a Dutch and a Swedish community in different periods.

Methods: Eight-year follow-up patterns of use were investigated with respect to the characteristics of those who continued use over the whole follow-up period. In the Dutch community of 13,500, the data of a cohort of 1358 benzodiazepine users were analysed during the years 1984-1991; in the Swedish community of 20,000 people, a cohort of 2038 benzodiazepine users was followed from 1976.

Results: At the end of the follow-up period, 32.9% of the Dutch cohort and 33% of the Swedish cohort had continued use of benzodiazepines. The two overall survival curves showed similar patterns. Stratification for age, gender, previous versus initial use and heavy versus non-heavy use showed comparable proportions of patients continuing benzodiazepine use over time.

Conclusion: The parallels in the results of two cohorts in different countries and different periods are striking and give support to the idea to stimulate interventions to reduce long-term benzodiazepine use.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anti-Anxiety Agents / administration & dosage*
  • Anti-Anxiety Agents / therapeutic use*
  • Benzodiazepines
  • Cohort Studies
  • Databases, Factual
  • Drug Administration Schedule
  • Drug Utilization Review*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Netherlands
  • Sex Factors
  • Substance-Related Disorders / epidemiology
  • Sweden
  • Time Factors

Substances

  • Anti-Anxiety Agents
  • Benzodiazepines