Abstract
Drug-drug interactions in the field of infectious diseases continue to expand as new drugs are approved, metabolic enzymes and transporters are identified, and recommendations for co-administration of drugs are revised. This article provides an overview of the principles and mechanisms of drug-drug interactions and describes pharmacokinetic-pharmacodynamic interactions commonly associated with antibacterial therapy, antiviral agents (non-retroviral), and drugs for tuberculosis.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors
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Aminoglycosides / therapeutic use
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Anti-Bacterial Agents / therapeutic use*
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Antitubercular Agents / therapeutic use
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Antiviral Agents / therapeutic use
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Chloramphenicol / therapeutic use
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Ciprofloxacin / therapeutic use
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Cytochrome P-450 Enzyme Inhibitors
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Cytochrome P-450 Enzyme System / metabolism
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Drug Interactions*
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Fluoroquinolones / therapeutic use
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Gastrointestinal Tract / drug effects
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Gastrointestinal Tract / microbiology
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Histamine H2 Antagonists / therapeutic use
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Humans
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Influenza A virus / drug effects
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Macrolides / therapeutic use
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Pharmacokinetics
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Tetracyclines / therapeutic use
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beta-Lactams / therapeutic use
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Aminoglycosides
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Anti-Bacterial Agents
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Antitubercular Agents
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Antiviral Agents
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Cytochrome P-450 Enzyme Inhibitors
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Fluoroquinolones
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Histamine H2 Antagonists
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Macrolides
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Tetracyclines
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beta-Lactams
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Ciprofloxacin
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Chloramphenicol
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Cytochrome P-450 Enzyme System