Antibiotic drug interactions

Med Clin North Am. 2006 Nov;90(6):1223-55. doi: 10.1016/j.mcna.2006.06.008.

Abstract

Drug-drug interactions in the field of infectious diseases continue to expand as new drugs are approved, metabolic enzymes and transporters are identified, and recommendations for co-administration of drugs are revised. This article provides an overview of the principles and mechanisms of drug-drug interactions and describes pharmacokinetic-pharmacodynamic interactions commonly associated with antibacterial therapy, antiviral agents (non-retroviral), and drugs for tuberculosis.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors
  • Aminoglycosides / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Antitubercular Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • Chloramphenicol / therapeutic use
  • Ciprofloxacin / therapeutic use
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions*
  • Fluoroquinolones / therapeutic use
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / microbiology
  • Histamine H2 Antagonists / therapeutic use
  • Humans
  • Influenza A virus / drug effects
  • Macrolides / therapeutic use
  • Pharmacokinetics
  • Tetracyclines / therapeutic use
  • beta-Lactams / therapeutic use

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antitubercular Agents
  • Antiviral Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Fluoroquinolones
  • Histamine H2 Antagonists
  • Macrolides
  • Tetracyclines
  • beta-Lactams
  • Ciprofloxacin
  • Chloramphenicol
  • Cytochrome P-450 Enzyme System