In children pre-anaesthetic medications are frequently administered as pharmacological adjunctions to help alleviate the stress and fear of surgery as well as to ease child parental separation and promote a smooth induction. Oral, rectal, intravenous and intramuscular route has been used; however each route has its disadvantage. Pre-anaesthetic medication administered intranasal for avoidance of painful injection have made it a convenient way to pre-medication. To evaluate the efficacy of intranasal administered Midazolam 0.2 mg/kg and Ketamine 5 mg/kg respectively. Total 50 patients of ASA I and II of age group 1- 7 years, mean age 3.88 +/- 1.26 and 4.56 +/- 1.21 were included in group I and group II respectively, and Scheduled for elective surgery. Mean time of separation was 17.12 +/- 1.21 in-group I and 15.68+11.62 in group II with P value < 0.001 and 0.322, shows significant difference during time of separation from parents and no significant difference for i.v. line insertion in both groups.