Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro

Calcif Tissue Int. 1986 Feb;38(2):123-5. doi: 10.1007/BF02556841.

Abstract

Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors*
  • Animals
  • Benzimidazoles / pharmacology*
  • Bone Resorption / drug effects*
  • Calcium / metabolism
  • H(+)-K(+)-Exchanging ATPase
  • In Vitro Techniques
  • Mice
  • Omeprazole
  • Osteoclasts / drug effects
  • Osteoclasts / metabolism

Substances

  • Benzimidazoles
  • Adenosine Triphosphatases
  • H(+)-K(+)-Exchanging ATPase
  • Omeprazole
  • Calcium