Abstract
Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphatases / antagonists & inhibitors*
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Animals
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Benzimidazoles / pharmacology*
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Bone Resorption / drug effects*
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Calcium / metabolism
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H(+)-K(+)-Exchanging ATPase
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In Vitro Techniques
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Mice
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Omeprazole
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Osteoclasts / drug effects
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Osteoclasts / metabolism
Substances
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Benzimidazoles
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Adenosine Triphosphatases
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H(+)-K(+)-Exchanging ATPase
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Omeprazole
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Calcium