The aim of this study was to describe the safety and effectiveness associated with phenol matricectomy in patients with diabetes. To date, the medical literature is devoid of information regarding the use of chemical toenail matricectomies performed on patients with diabetes. Sixty-six consecutive patients with diabetes and ingrown toenails were evaluated. The procedure was performed on 57 of these patients. The results demonstrate a 5% regrowth rate, no significant complications, and limited risk in this patient population.